Transition From Methadone to Buprenorphine Using a Short-acting Agonist Bridge in the Inpatient Setting: A Case Study
| Autor: | Julia Ross, Jarratt D. Pytell, Darius A. Rastegar, Jonathan Callan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Agonist
medicine.medical_specialty medicine.drug_class 01 natural sciences 03 medical and health sciences 0302 clinical medicine Opiate Substitution Treatment medicine Humans Pharmacology (medical) 030212 general & internal medicine 0101 mathematics Intensive care medicine Inpatients business.industry 010102 general mathematics Opioid use disorder Inpatient setting Opioid-Related Disorders medicine.disease Hydromorphone Buprenorphine Substance Withdrawal Syndrome Analgesics Opioid Psychiatry and Mental health Opioid business Methadone medicine.drug |
| Zdroj: | Journal of Addiction Medicine. 14:e274-e276 |
| ISSN: | 1935-3227 1932-0620 |
| DOI: | 10.1097/adm.0000000000000623 |
| Popis: | Methadone and buprenorphine are the most common medications for opioid use disorder. Buprenorphine is often the preferred medication because of fewer drug-drug interactions and fewer regulatory barriers. For these reasons, patients often desire to transition from methadone to buprenorphine, but this can be difficult because of the risk of precipitated withdrawal. There are protocols designed to minimize withdrawal; however, these can be time-consuming or infeasible due to formulation and dosage availability of buprenorphine. We describe an inpatient transition from methadone to buprenorphine using a hydromorphone bridge over a 7-day period. This method used commonly available dosages and formulations of buprenorphine. To our knowledge, this is the first time a method has been described that transitions a patient from methadone to buprenorphine using a short-acting opioid agonist bridge and readily available opioid dosages and formulations. This case provides a viable alternative for rapidly transitioning a patient from methadone to buprenorphine that can be used as a template for an alternative method to transitions between these medications. |
| Databáze: | OpenAIRE |
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