Restrictive Atrial Septum Defect Becomes a Risk Factor for Norwood Palliation of Hypoplastic Left Heart Syndrome Only When It Is Combined with Mitral or Aortic Atresia
| Autor: | Nicodème Sinzobahamvya, Peter Zartner, Boulos Asfour, Viktor Hraska, S Sata, Claudia Arenz |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Heart Defects
Congenital Male Pulmonary and Respiratory Medicine medicine.medical_specialty Time Factors medicine.medical_treatment Kaplan-Meier Estimate Norwood Procedures Risk Assessment Heart Septal Defects Atrial Statistics Nonparametric Hypoplastic left heart syndrome Cohort Studies Aortic Valve Atresia Internal medicine Mitral valve Hypoplastic Left Heart Syndrome Confidence Intervals medicine Humans Abnormalities Multiple Retrospective Studies Heart septal defect business.industry Infant medicine.disease Survival Analysis Pulmonary hypertension Norwood Operation Stenosis Treatment Outcome medicine.anatomical_structure Aortic Valve Multivariate Analysis Cardiology Mitral Valve Female Surgery Norwood procedure Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | The Thoracic and Cardiovascular Surgeon. 63:354-359 |
| ISSN: | 1439-1902 0171-6425 |
| DOI: | 10.1055/s-0034-1374060 |
| Popis: | BACKGROUND Restrictive atrial septal defect (ASD) is described as risk factor for Norwood procedure because of elevated pulmonary resistance. We hypothesized that it invariably could not cause pulmonary hypertension, unless it was combined with mitral valve or aortic valve atresia. We investigated how restrictive ASD influenced survival of patients with hypoplastic left heart syndrome (HLHS) who underwent Norwood operation. PATIENTS AND METHODS A total of 118 HLHS patients who underwent surgery between January 2005 and December 2012 were grouped into three groups. Group 1 included 31 patients with restrictive ASD combined with mitral or aortic atresia; Group 2 composed of 12 patients with restrictive ASD and mitral and aortic stenosis; Group 3 (n = 75) had no ASD restriction. Survival was determined for each group. Multivariate analysis was conducted to test risk factors for mortality. RESULTS Mean follow-up was 26.3 ± 24.1 months. Survival was 78.7% ± 4.2% at 30-month interval and onward after Norwood procedure for the whole cohort; it was 43.8% ± 10.0%, 91.7% ± 8.0%, and 77.3% ± 5.0% for Group 1, 2, and 3, respectively. The difference was significant between Group 1 and Group 2 and 3: p |
| Databáze: | OpenAIRE |
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