Odd chain fatty acids:new insights of the relationship between the gut microbiota, dietary intake, biosynthesis and glucose intolerance

Autor: Kaija J. Autio, Kalervo Hiltunen, Kevin Seyssel, Stéphane Hazebrouck, Ronald M. Krauss, Mary Courtney Moore, Pin-Ho Pan, Keith Summerhill, Renata Stepankova, Zsuzsanna Ament, Shih-Yi Lin, James A. West, Evelyn de Schryver, Julian L. Griffin, Walter Vetter, Albert Koulman, Sally Chiu, Martine Laville, Benjamin Jenkins, Sarah King, Martin J. J. Ronis, Alan D. Cherrington, Elizabeth Stanley, Chun-Jung Chen, Maud Alligier, Paul P. Van Veldhoven, Guillaume Kraft
Přispěvatelé: Medical Research Council Human Nutrition Research, University of Cambridge, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Oakland Research Institute, All Children’s Hospital, Department Pediatric, Tungs' Taichung Metroharbor Hospital, Center Geriatric and Gerontology, Division Endocrinology and Metabolic, Taichung Veterans General Hospital, Institute Food Chemistry, University of Hohenheim, Biocenter Oulu, Faculty Biochemistry and Molecular Medicine, University of Oulu, Laboratoire d'Etudes et de Recherches en Immunoanalyses (LERI), Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Médicaments et Technologies pour la Santé (MTS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institute Microbiology, Laboratory of Gnotobiology, Czech Academy of Sciences [Prague] (ASCR), Department of Medical Research, School Medicine, Department Molecular Physiology and Biophysics, Vanderbilt University [Nashville], Laboratory Lipid Biochemistry and Protein Interaction LIPIT, Université Catholique de Louvain, NIHR BRC Core Metabolic aand Lipid Laboratory, Cambridge University Hospitals (CUH), Medical Research Council for core funding UD99999906, Cambridge Lipidomics Biomarker Research Initiative G0800783, MRC Human Nutrition Research, GACR GA15-09518S, Czech Science Foundation, GACR 16-06326S, USDA ( ACNC-USDA-CRIS) 6251-51000- 005-03S, Hospices Civils de Lyon, Programme Hospitalier de Recherche Clinique Interregional, Agence Nationale de la Recherche (Programme de Recherche en Nutrition Humaine and the Programme National de Recherche en Alimentation), Innovation Strategique Industrielle program of the Agence pour l' Innovation OSEO, Academy of Finland 138690, Sigrid Juselius Foundation and NordForsk under the Nordic Centres of Excellence Programme in Food, Nutrition and Health 070010, NIH R01-DK-18243, Flemish 'Fonds Wetenschappelijk Onderzoek' G.0721.10N, KU Leuven OT/14/100, Ministere de l' Enseignement Superieur et de la Recherche (France), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Médicaments et Technologies pour la Santé (MTS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Czech Academy of Sciences [Prague] (CAS), Université Catholique de Louvain = Catholic University of Louvain (UCL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), West, James [0000-0002-1535-7737], Griffin, Julian [0000-0003-1336-7744], Koulman, Albert [0000-0001-9998-051X], Apollo - University of Cambridge Repository
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Gerontology
Dietary Sugars
[SDV]Life Sciences [q-bio]
microbiote digestif
Gut flora
0601 Biochemistry and Cell Biology
biosynthèse
Oral and gastrointestinal
Mice
Medicine
Lipid profiling
Animal study
glucose
2. Zero hunger
Multidisciplinary
biology
acide gras
Dietary intake
Fatty Acids
3. Good health
endocrine system
0299 Other Physical Sciences
Library science
Human study
Research initiative
Article
03 medical and health sciences
Glucose Intolerance
Animals
Humans
Metabolic and endocrine
Nutrition
Extramural
business.industry
Prevention
predictive markers
Glucose Tolerance Test
biology.organism_classification
Dietary Fats
Biosynthetic Pathways
Diet
Gastrointestinal Microbiome
Rats
stomatognathic diseases
030104 developmental biology
Dietary Supplements
lipidomics
Fat supplementation
fatty acid
biosynthesis
business
Digestive Diseases
apport alimentaire
intolérance
Zdroj: Scientific Reports
Scientific reports, vol 7, iss 1
Scientific Reports, Nature Publishing Group, 2017, 7, ⟨10.1038/srep44845⟩
Scientific Reports (7), . (2017)
Scientific Reports, 2017, 7, ⟨10.1038/srep44845⟩
ISSN: 2045-2322
Popis: Recent findings have shown an inverse association between circulating C15:0/C17:0 fatty acids with disease risk, therefore, their origin needs to be determined to understanding their role in these pathologies. Through combinations of both animal and human intervention studies, we comprehensively investigated all possible contributions of these fatty acids from the gut-microbiota, the diet, and novel endogenous biosynthesis. Investigations included an intestinal germ-free study and a C15:0/C17:0 diet dose response study. Endogenous production was assessed through: a stearic acid infusion, phytol supplementation, and a Hacl1−/− mouse model. Two human dietary intervention studies were used to translate the results. Finally, a study comparing baseline C15:0/C17:0 with the prognosis of glucose intolerance. We found that circulating C15:0/C17:0 levels were not influenced by the gut-microbiota. The dose response study showed C15:0 had a linear response, however C17:0 was not directly correlated. The phytol supplementation only decreased C17:0. Stearic acid infusion only increased C17:0. Hacl1−/− only decreased C17:0. The glucose intolerance study showed only C17:0 correlated with prognosis. To summarise, circulating C15:0 and C17:0 are independently derived; C15:0 correlates directly with dietary intake, while C17:0 is substantially biosynthesized, therefore, they are not homologous in the aetiology of metabolic disease. Our findings emphasize the importance of the biosynthesis of C17:0 and recognizing its link with metabolic disease.
Databáze: OpenAIRE
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