Tau–FG-nucleoporin98 interaction and impaired nucleocytoplasmic transport in Alzheimer’s disease

Autor:	Timir Tripathi, Niharika Nag
Rok vydání:	2022
Předmět:	Genetics General Medicine Molecular Biology Biochemistry
Zdroj:	Briefings in Functional Genomics. 22:161-167
ISSN:	2041-2657 2041-2649
Popis:	An emerging pathophysiology associated with the neurodegenerative Alzheimer’s disease (AD) is the impairment of nucleocytoplasmic transport (NCT). The impairment can originate from damage to the nuclear pore complex (NPC) or other factors involved in NCT. The phenylalanine-glycine nucleoporins (FG-Nups) form a crucial component of the NPC, which is central to NCT. Recent discoveries have highlighted that the neuropathological protein tau is involved in direct interactions with the FG-Nups and impairment of the NCT process. Targeting such interactions may lead to the identification of novel interaction inhibitors and offer new therapeutic alternatives for the treatment of AD. This review highlights recent findings associated with impaired NCT in AD and the interaction between tau and the FG-Nups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2767c60b0558d64709aa9346f78c6d9 https://doi.org/10.1093/bfgp/elac022 Zobrazit plný text záznamu