Levels of predominant intestinal microorganisms in 1 month-old full-term babies and weight gain during the first year of life
| Autor: | Gonzalo Solís, Cecilia Martínez-Costa, Marta Suárez, Susana Díaz-Coto, Maria Carmen Collado, Miguel Gueimonde, Marta Selma-Royo, Silvia Arboleya, Sonia González, Clara G. de los Reyes-Gavilán, Nuria Fernández, Pablo Martínez-Camblor |
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| Přispěvatelé: | Ministerio de Ciencia, Innovación y Universidades (España), European Commission, European Research Council |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Staphylococcus Physiology First year of life Gut flora Enterococcus Feces Child Development 0302 clinical medicine Medicine TX341-641 Nutrition and Dietetics biology infants Microbiota Age Factors weight gain 3. Good health Intestines Cohort Female medicine.symptom Infants Term Birth Context (language use) Article 03 medical and health sciences 030225 pediatrics microbiota Humans Weight gain Full Term Intestinal microorganisms Bacteria Nutrition. Foods and food supply Cesarean Section business.industry Bifidobacterium Infant Newborn Infant biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology Spain business Food Science |
| Zdroj: | Scopus RUO. Repositorio Institucional de la Universidad de Oviedo instname Nutrients Digital.CSIC: Repositorio Institucional del CSIC Consejo Superior de Investigaciones Científicas (CSIC) Digital.CSIC. Repositorio Institucional del CSIC Volume 13 Issue 7 Nutrients, Vol 13, Iss 2412, p 2412 (2021) |
| Popis: | The early life gut microbiota has been reported to be involved in neonatal weight gain and later infant growth. Therefore, this early microbiota may constitute a target for the promotion of healthy neonatal growth and development with potential consequences for later life. Unfortunately, we are still far from understanding the association between neonatal microbiota and weight gain and growth. In this context, we evaluated the relationship between early microbiota and weight in a cohort of full-term infants. The absolute levels of specific fecal microorganisms were determined in 88 vaginally delivered and 36 C-section-delivered full-term newborns at 1 month of age and their growth up to 12 months of age. We observed statistically significant associations between the levels of some early life gut microbes and infant weight gain during the first year of life. Classifying the infants into tertiles according to their Staphylococcus levels at 1 month of age allowed us to observe a significantly lower weight at 12 months of life in the C-section-delivered infants from the highest tertile. Univariate and multivariate models pointed out associations between the levels of some fecal microorganisms at 1 month of age and weight gain at 6 and 12 months. Interestingly, these associations were different in vaginally and C-section-delivered babies. A significant direct association between Staphylococcus and weight gain at 1 month of life was observed in vaginally delivered babies, whereas in C-section-delivered infants, lower Bacteroides levels at 1 month were associated with higher later weight gain (at 6 and 12 months). Our results indicate an association between the gut microbiota and weight gain in early life and highlight potential microbial predictors for later weight gain. This work was funded by the EU Joint Programming Initiative—A Healthy Diet for a Healthy Life (JPI HDHL. http://www.healthydietforhealthylife.eu/; accessed on 14 July 2021. Project EarlyMicroHealth) and the Project AGL2017-83653R funded by the Spanish “Ministerio de Ciencia, Innovación y Universidades (MCIU), Agencia Estatal de Investigación (AEI) and FEDER” and by the European Research Council under the European Union’s Horizon 2020 research and innovation program (ERC starting grant, no. 639226). Silvia Arboleya is the recipient of a Juan de la Cierva Postdoctoral Contract from the Spanish Ministry of Science and Innovation (Ref. IJCI-2017-32156) funded by the Spanish Ministry of Science, Innovation and Universities. |
| Databáze: | OpenAIRE |
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