Endocytosis of Hedgehog through Dispatched Regulates Long-Range Signaling
| Autor: | Gisela D'Angelo, Pascal P. Thérond, Sandrine Pizette, Tamás Matusek |
|---|---|
| Přispěvatelé: | Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), D'ANGELO, Gisela, Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
MESH: Signal Transduction
MESH: Drosophila Proteins [SDV]Life Sciences [q-bio] Cell Biology Endocytosis General Biochemistry Genetics and Molecular Biology MESH: Wings Animal MESH: Drosophila melanogaster MESH: Gene Expression Regulation Developmental medicine Animals Drosophila Proteins Wings Animal Hedgehog Proteins Secretion MESH: Animals MESH: rab5 GTP-Binding Proteins Molecular Biology Hedgehog [SDV.BDD]Life Sciences [q-bio]/Development Biology rab5 GTP-Binding Proteins Regulation of gene expression rab4 GTP-Binding Proteins Gene Expression Regulation Developmental Transporter Cell Biology MESH: Hedgehog Proteins Cell biology [SDV] Life Sciences [q-bio] Imaginal disc Drosophila melanogaster medicine.anatomical_structure Secretory protein MESH: Metabolic Networks and Pathways MESH: Endocytosis Metabolic Networks and Pathways MESH: rab4 GTP-Binding Proteins Signal Transduction Developmental Biology |
| Zdroj: | Developmental Cell Developmental Cell, 2015, 32 (3), pp.290-303. ⟨10.1016/j.devcel.2014.12.004⟩ Developmental Cell, Elsevier, 2015, 32 (3), pp.290-303. ⟨10.1016/j.devcel.2014.12.004⟩ HAL Developmental Cell, Elsevier, 2015, 32 (3), pp.290-303 |
| ISSN: | 1534-5807 |
| Popis: | International audience; The proteins of the Hedgehog (Hh) family are secreted proteins exerting short- and long-range control over various cell fates in developmental patterning. The Hh gradient in Drosophila wing imaginal discs consists of apical and basolateral secreted pools, but the mechanisms governing the overall establishment of the gradient remain unclear. We investigated the relative contributions of endocytosis and recycling to control the Hh gradient. We show that, upon its initial apical secretion, Hh is re-internalized. We examined the effect of the resistance-nodulation-division transporter Dispatched (Disp) on long-range Hh signaling and unexpectedly found that Disp is specifically required for apical endocytosis of Hh. Re-internalized Hh is then regulated in a Rab5- and Rab4-dependent manner to ensure its long-range activity. We propose that Hh-producing cells integrate endocytosis and recycling as two instrumental mechanisms contributing to regulate the long-range activity of Hh. |
| Databáze: | OpenAIRE |
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