α-Glucosidase inhibitory activities of isoflavanones, isoflavones, and pterocarpans from Mucuna pruriens
| Autor: | Vilailak Prachyawarakorn, Chulabhorn Mahidol, Somsak Ruchirawat, Tshewang Dendup, Acharavadee Pansanit, Prasat Kittakoop |
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| Rok vydání: | 2014 |
| Předmět: |
Circular dichroism
Magnetic Resonance Spectroscopy Pterocarpans Cell Survival Pharmaceutical Science Plant Roots Analytical Chemistry Cell Line chemistry.chemical_compound Drug Discovery medicine Humans Medicarpin Glycoside Hydrolase Inhibitors α glucosidase inhibitory Acarbose Pharmacology Plants Medicinal Traditional medicine biology Molecular Structure Plant Extracts Organic Chemistry Pterocarpan alpha-Glucosidases Fabaceae Isoflavones biology.organism_classification Mucuna Complementary and alternative medicine chemistry Biochemistry Molecular Medicine Seasons Mucuna pruriens medicine.drug |
| Zdroj: | Planta medica. 80(7) |
| ISSN: | 1439-0221 |
| Popis: | Three new isoflavanones (1–3) and thirteen known compounds (4–16) were isolated from the roots of Mucuna pruriens. The absolute configurations of isoflavanones 1–3 and parvisoflavanone (4), lespedeol C (5), and uncinanone C (6) were addressed by a circular dichroism technique. Isoflavanones, isoflavones, and pterocarpans of M. pruriens were found to be α-glucosidase inhibitors. Medicarpin (7) and parvisoflavone B (9) were potent α-glucosidase inhibitors (twofold less active than the standard drug acarbose). The production of bioactive metabolites in M. pruriens seems to be season-dependent. |
| Databáze: | OpenAIRE |
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