Outcomes of Definitive Chemoradiotherapy for Stage IVa (T4b vs. N4) Esophageal Squamous Cell Carcinoma Based on the Japanese Classification System: A Retrospective Single-Center Study
| Autor: | Yuki Wada, Satoshi Kumagai, Yusuke Sato, Eriko Okuyama, Akira Anbai, Noriko Takagi, Hiroshi Nanjo, Satoru Motoyama, Manabu Hashimoto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Single Center lcsh:RC254-282 Esophageal squamous cell carcinoma Article external beam radiation therapy 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Stage (cooking) business.industry locally advanced esophageal cancer Cancer Common Terminology Criteria for Adverse Events Definitive chemoradiotherapy lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Confidence interval esophageal squamous cell carcinoma definitive chemoradiation therapy 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology business Chemoradiotherapy |
| Zdroj: | Cancers Volume 13 Issue 1 Cancers, Vol 13, Iss 8, p 8 (2021) |
| ISSN: | 2072-6694 |
| Popis: | The differences in prognoses or progression patterns between T4b non-N4 and non-T4b N4 esophageal squamous cell carcinoma post chemoradiotherapy (CRT) is unclear. This study compared the outcomes of CRT for stage IVa esophageal squamous cell carcinoma according to T/N factors. We retrospectively identified 66 patients with stage IVa esophageal squamous cell carcinoma who underwent definitive CRT at our center between January 2009 and March 2013. The treatment outcomes, i.e., progression patterns, prognostic factors, and toxicities based on version 5.0 of the National Cancer Institute Common Terminology Criteria for Adverse Events, were studied. The patients (56 men and 10 women) had a median age of 67 (range: 37&ndash 87) years. The T/N classifications were T4b non-N4 (28/66), non-T4b N4 (24/66), and T4b N4 (14/66). Objective response was achieved in 57 patients (86.4%, (95% confidence interval, 74.6&ndash 94.1%)). There were no significant differences between the T/N groups in terms of overall survival, progression-free survival, and progression pattern. We found no significant differences in prognoses or progression patterns among patients with T4b non-N4, non-T4b N4, and T4b N4 esophageal squamous cell carcinoma. Thus, it seems impractical to modify CRT regimens based on T/N factors. |
| Databáze: | OpenAIRE |
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