Complete or partial trisomy for the long arm of chromosome 1 in patients with various hematologic malignancies
| Autor: | N. M. Jartseva, L. V. Belyaeva, E. G. Scherbakova, S. E. Mamaeva, N. N. Mamaev |
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| Rok vydání: | 1983 |
| Předmět: |
Pathology
medicine.medical_specialty Cell Trisomy Biology Long arm Bone Marrow Genetics medicine Humans Metaphase Genetics (clinical) Leukemia Chromosomes Human 1-3 Chromosome Karyotype medicine.disease Molecular medicine Human genetics Chromosome Banding Leukemia Lymphoid medicine.anatomical_structure Leukemia Myeloid Karyotyping Acute Disease Immunology Bone marrow |
| Zdroj: | Human Genetics. 63:107-112 |
| ISSN: | 1432-1203 0340-6717 |
| DOI: | 10.1007/bf00291527 |
| Popis: | This study contains data obtained from a cytogenetic investigation of six patients with acute and chronic leukaemia. The karyotypes of bone marrow or blood cells of these patients showed a partial or complete trisomy for the long arm of chromosome 1. Three observations revealed a pronounced resistance of cell clones with 1q+ towards cytostatic therapy, and a comparatively short life span of patients after detection of 1q+. The importance of these changes for the role of some chromosomes and chromosome loci in leukaemogenesis is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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