Evaluation of Neointimal Hyperplasia on Tranilast-Coated Synthetic Vascular Grafts: An Experimental Study

Autor:	Aydin Akdur, Feza Karakayali, Mehmet Haberal, Nesrin Hasirci, Aysel Kiziltay, Nihan Haberal, Hale Tufan, Sinasi Sevmis, Özgür Başaran
Rok vydání:	2007
Předmět:	medicine.medical_specialty Pathology Vascular smooth muscle Tranilast medicine.medical_treatment Fibroblast growth factor chemistry.chemical_compound Coated Materials Biocompatible Anti-Allergic Agents medicine Animals ortho-Aminobenzoates Rats Wistar Thrombus Polytetrafluoroethylene Neointimal hyperplasia Hyperplasia biology business.industry Growth factor Graft Survival Graft Occlusion Vascular medicine.disease Blood Vessel Prosthesis Rats Surgery Carotid Arteries chemistry biology.protein Tunica Intima business Platelet-derived growth factor receptor medicine.drug
Zdroj:	Journal of Investigative Surgery. 20:167-173
ISSN:	1521-0553 0894-1939
DOI:	10.1080/08941930701365101
Popis:	Tranilast is an antiallergic drug that interferes with proliferation and migration of vascular smooth muscle cell induced by platelet-derived growth factor (PDGF) and transforming growth factor-beta1 (TGF-beta1). We investigated the local effect of tranilast on neointimal hyperplasia using tranilast-coated prosthetic grafts. The inner sides of the thin-walled polytetrafluoroethylene (PTFE) grafts were coated with chitosan and tranilast containing chitosan solution. Wistar albino rats (32) were used in the study. Patches (1 x 2 mm) for vascular grafts were prepared. Three groups were tested: group 1 (n = 12; tranilast coated), group 2 (n = 10; adhesive-only film-layer-coated), and group 3 (n = 10; normal ePTFE patch grafts sutured to the carotid arteries of the rats). Recipient sites of the carotid arteries were excised 4 weeks after surgery. All sections were examined histologically for graft patency, thrombus formation, and neointimal thickness. Expression of PDGF, fibroblast growth factor, and TGF-beta1 on cross-sections of the neointima were evaluated by immunohistochemistry. No significant differences were found regarding mean neointimal thicknesses. PDGF and TGF-beta-1 expressions were significantly lower in group 1. Although a decrease in local effect of tranilast was observed for growth factor expressions at a drug concentration of 0.05 mg/cm(2), a significant reduction in neointimal hyperplasia was not achieved. The coating concentration of 0.05 mg/cm(2) may have been too low to produce an antiproliferative effect. Given our promising results, further studies are recommended and planned using different drug concentrations and time intervals.
Databáze:	OpenAIRE
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