Analysis of characteristics and outcomes by growth hormone treatment duration in adult patients in the Italian cohort of the Hypopituitary Control and Complications Study (HypoCCS)
| Autor: | Diego Ferone, C. Di Somma, Maurizio Poggi, Salvatore Cannavò, Maria Rosaria Ambrosio, Gianluca Aimaretti, Marco Losa, Paolo Beck-Peccoz, Carla Scaroni, Nan Jia, Vincenzo Rochira, Gilberto Mossetto, Antonella Giampietro, Carla Lubrano, Salvatore Maria Corsello |
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| Přispěvatelé: | Rochira, V., Mossetto, G., Jia, N., Cannavo, S., Beck-Peccoz, P., Aimaretti, G., Ambrosio, M. R., Di Somma, C., Losa, M., Ferone, D., Lubrano, C., Scaroni, C., Giampietro, A., Corsello, S. M., Poggi, M. |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Endocrinology Diabetes and Metabolism Longitudinal Studie Sex Factor Adult GH dose growth hormone deficiency growth hormone treatment insulin-like growth factor-I lipid profile endocrinology diabetes and metabolism endocrinology Body Mass Index Cohort Studies 0302 clinical medicine Endocrinology Quality of life Age Factor insulin-like growth factor-I Longitudinal Studies Insulin-Like Growth Factor I diabetes and metabolism medicine.diagnostic_test Human Growth Hormone Age Factors growth hormone treatment Middle Aged Growth hormone treatment Lipid profile Diabetes and Metabolism lipid profile Treatment Outcome Italy 030220 oncology & carcinogenesis Cohort Female Original Article Analysis of variance Drug Human Adult growth hormone deficiency medicine.medical_specialty Hormone Replacement Therapy 030209 endocrinology & metabolism Hypopituitarism NO Growth hormone deficiency Dose-Response Relationship 03 medical and health sciences GH dose Insulin-like growth factor-I endocrinology Sex Factors Internal medicine medicine Humans Medical history Dose-Response Relationship Drug business.industry medicine.disease Cohort Studie business Body mass index |
| Zdroj: | Journal of Endocrinological Investigation |
| Popis: | Purpose: To examine differences in effects according to growth hormone (GH) treatment duration in adult GH-deficient patients. Methods: In the Italian cohort of the observational Hypopituitary Control and Complications Study, GH-treated adults with GH deficiency (GHD) were grouped by duration of treatment; ≤ 2 years (n = 451), > 2 to ≤ 6 years (n = 387) and > 6 years (n = 395). Between-group differences in demographics, medical history, physical characteristics, insulin-like growth factor-I standard deviation score (IGF-I SDS) and lipid profile at baseline, last study visit and changes from baseline to last study visit were assessed overall, for adult- and childhood-onset GHD and by gender using ANOVA for continuous variables and Chi-squared test for categorical variables. Results: At baseline, treatment duration groups did not differ significantly for age, gender, body mass index, GHD onset, IGF-I SDS, lipid profile, and quality of life. Mean initial GH dose did not differ significantly according to treatment duration group in any subgroup, except female patients, with highest mean dose seen in the longest duration group. In the longest duration group for patients overall, adult-onset patients and male patients, there were significant decreases in GH dose from baseline to last visit, and in total and low-density lipoprotein (LDL)-cholesterol concentrations. IGF-I SDS increased, to a greater extent, in the longest duration group for patients overall and female patients. Conclusions: The results show that long-term GH treatment is associated with decreasing GH dose, increased IGF-I, decreased LDL-cholesterol and the presence of surrogate markers that help to give confidence in a diagnosis of GHD. |
| Databáze: | OpenAIRE |
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