Short Therapeutic Window for MK-801 in Transient Focal Cerebral Ischemia in Normotensive Rats
| Autor: | Isabelle Margaill, Roger G. Boulu, S. Parmentier, Jacques Callebert, Michel Plotkine, Monique Allix |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Microdialysis Ischemia Glutamic Acid Striatum Receptors N-Methyl-D-Aspartate Neuroprotection 030218 nuclear medicine & medical imaging Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals cardiovascular diseases Receptor Cerebral Cortex Analysis of Variance business.industry Glutamate receptor Antagonist Cerebral Infarction medicine.disease Corpus Striatum Rats Disease Models Animal Neurology Ischemic Attack Transient Anesthesia Reperfusion Cardiology NMDA receptor Neurology (clinical) Dizocilpine Maleate Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Cerebral Blood Flow & Metabolism. 16:107-113 |
| ISSN: | 1559-7016 0271-678X |
| DOI: | 10.1097/00004647-199601000-00013 |
| Popis: | The present study investigates the role of N-methyl-D-aspartate (NMDA) receptors in a model of transient focal cerebral ischemia in normotensive rats. The left middle cerebral artery and both common carotid arteries were occluded for 60 min. Preliminary studies indicated that this gave reproducible infarctions of the cortex and striatum. These infarctions were the result of severe ischemia followed by complete reperfusion after clamp removal, as showed by striatal tissue Po2 monitoring. Microdialysis indicated that glutamate concentration increased immediately after occlusion and returned to the baseline value 40 min after clamp removal. MK-801 (1 mg kg−1 i.v.), an antagonist of the NMDA glutamatergic receptor, reduced the cortical infarct volume by 29% (p < 0.001) and the striatal infarct volume by 14% (p < 0.05) when given just prior to ischemia, but had no neuroprotective activity when given 30 min after the onset of ischemia. This short therapeutic window for MK-801 suggests that NMDA receptors play only a transient role in reversible focal ischemia in rats. |
| Databáze: | OpenAIRE |
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