Non-metastatic cutaneous squamous cell carcinoma treated with photodynamic therapy using intravenous mTHPC
| Autor: | Colin Hopper, Aamr A. Yousif, Zaid Hamdoon, Waseem Jerjes |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms Cutaneous squamous cell carcinoma medicine.medical_treatment 030303 biophysics Biophysics Antineoplastic Agents Photodynamic therapy Dermatology Lesion 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Humans Medicine Outpatient clinic Pharmacology (medical) Infusions Intravenous Vein Response Evaluation Criteria in Solid Tumors Aged Neoplasm Staging Retrospective Studies 0303 health sciences Photosensitizing Agents business.industry Remission Induction Retrospective cohort study Middle Aged medicine.disease medicine.anatomical_structure Mesoporphyrins Photochemotherapy Oncology Carcinoma Squamous Cell Female Radiology Lasers Semiconductor Skin cancer medicine.symptom business |
| Zdroj: | Photodiagnosis and Photodynamic Therapy. 28:172-176 |
| ISSN: | 1572-1000 |
| Popis: | Photodynamic therapy (PDT) is a method of treating various pathologies. In this retrospective study with prospective intent, a total of 22 patients with T1/T2 N0 cutaneous squamous cell carcinoma (SCC) were treated with intravenous mTHPC (meta-tetrahydroxyphenylchlorin) and surface illumination PDT. Comparisons with the clinical features, rate of recurrence and overall outcome were made.Surface illumination PDT was offered under local anaesthesia. 0.05 mg/kg mTHPC was administered intravenously into the midcubital vein 48 h prior to tissue illumination. A single-channel 652 nm diode laser was used for illumination and light was delivered at 20 J/cmClinical assessment revealed that 16 patients had lesions of2 cm in size (T1), while the rest were T2. No nodal involvement was identified in any of the patients. None of the patients had a locally recurrent lesion. During the 3-year follow-up, 20/22 patients had complete response (CR) and this was after one round of treatment. Two patients suffered from recurrent disease within 3 years of the follow-up, and they underwent surgical resection.PDT achieved high efficacy in the treatment of T1N0 cutaneous squamous cell carcinoma with greatly reduced morbidity and disfigurement. The technique is simple, can commonly be carried out in outpatient clinics, and is highly acceptable to patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect