Allogeneic fibroblasts and endothelial cells support mitogen but not antigen responses of tetanus-responsive T-cell lines
| Autor: | S.J. Padula, W.R. Shanahan, Joseph H. Korn, R.B. Clark |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
T-Lymphocytes
T cell Immunology Antigen presentation Antigen-Presenting Cells chemical and pharmacologic phenomena In Vitro Techniques Biology Lymphocyte Activation Monocytes Cell Line Pathology and Forensic Medicine Immune system Cell–cell interaction Antigen Tetanus Toxoid medicine Humans Immunology and Allergy Endothelium Antigen-presenting cell Macrophages T lymphocyte Fibroblasts Molecular biology Endothelial stem cell medicine.anatomical_structure Mitogens |
| Zdroj: | Clinical Immunology and Immunopathology. 43:204-210 |
| ISSN: | 0090-1229 |
| Popis: | Recent studies suggest a role for endothelial cells (EC) and fibroblasts (FB) in performing certain accessory functions of monocytes in immune responses. We examined the ability of allogeneic adherent cells (AC), umbilical vein EC, and foreskin FB to support antigen and mitogen responses of tetanus toxoid-responsive human T-cell lines (TC Tet ). Syngeneic AC supported antigen and mitogen (phytohemagglutinin and poke-weed mitogen, PHA and PWM) responses of TC Tet . Allogeneic AC, EC, and FB supported mitogen but not antigen responses of TC Tet , in a dose-dependent manner. PHA-activated mononuclear cell supernates or EC or FB supernates could not replace accessory cells in mitogen responses. We provide further evidence that EC and FB can function as fully competent accessory cells, a function that may be of significance in in vivo initiation of immune responses. |
| Databáze: | OpenAIRE |
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