Risperidone-induced topological alterations of anatomical brain network in first-episode drug-naive schizophrenia patients: a longitudinal diffusion tensor imaging study
| Autor: | Jinsong Tang, J. John Mann, Y. Li, Luxian Lv, Yanhui Liao, Zongchang Li, Hong-Zeng Zhao, Deen Sang, Jun Zhou, Spiro P. Pantazatos, Ying He, Huafu Chen, Xiaogang Chen, Xiaofen Zong, Junjie Zheng, Maolin Hu |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Adolescent Prefrontal Cortex Topology Article White matter 03 medical and health sciences Young Adult 0302 clinical medicine Limbic system medicine Limbic System Humans Longitudinal Studies Prefrontal cortex Applied Psychology First episode Risperidone Positive and Negative Syndrome Scale business.industry medicine.disease White Matter 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Diffusion Tensor Imaging Schizophrenia Posterior cingulate Nerve Net business 030217 neurology & neurosurgery medicine.drug Antipsychotic Agents Follow-Up Studies |
| Zdroj: | Psychological medicine. 46(12) |
| ISSN: | 1469-8978 0033-2917 |
| Popis: | BackgroundIt remains unclear whether the topological deficits of the white matter network documented in cross-sectional studies of chronic schizophrenia patients are due to chronic illness or to other factors such as antipsychotic treatment effects. To answer this question, we evaluated the white matter network in medication-naive first-episode schizophrenia patients (FESP) before and after a course of treatment.MethodWe performed a longitudinal diffusion tensor imaging study in 42 drug-naive FESP at baseline and then after 8 weeks of risperidone monotherapy, and compared them with 38 healthy volunteers. Graph theory was utilized to calculate the topological characteristics of brain anatomical network. Patients’ clinical state was evaluated using the Positive and Negative Syndrome Scale (PANSS) before and after treatment.ResultsPretreatment, patients had relatively intact overall topological organizations, and deficient nodal topological properties primarily in prefrontal gyrus and limbic system components such as the bilateral anterior and posterior cingulate. Treatment with risperidone normalized topological parameters in the limbic system, and the enhancement positively correlated with the reduction in PANSS-positive symptoms. Prefrontal topological impairments persisted following treatment and negative symptoms did not improve.ConclusionsDuring the early phase of antipsychotic medication treatment there are region-specific alterations in white matter topological measures. Limbic white matter topological dysfunction improves with positive symptom reduction. Prefrontal deficits and negative symptoms are unresponsive to medication intervention, and prefrontal deficits are potential trait biomarkers and targets for negative symptom treatment development. |
| Databáze: | OpenAIRE |
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