Storage-induced increase in biomarkers of oxidative stress and inflammation in red blood cell components

Autor:	Karin Magnussen, Bülent Kücükakin, Jacob Rosenberg, Ismail Gögenur, Volkan Kocak, Jens Lykkesfeldt, Hans Jørgen Nielsen
Rok vydání:	2011
Předmět:	Erythrocytes Time Factors Blood transfusion medicine.medical_treatment alpha-Tocopherol Clinical Biochemistry Inflammation Ascorbic Acid Oxidative phosphorylation Biology medicine.disease_cause Andrology Blood cell chemistry.chemical_compound Adipokines Lectins Malondialdehyde medicine Humans Chitinase-3-Like Protein 1 Interleukin-6 General Medicine Oxidative Stress Red blood cell medicine.anatomical_structure chemistry Blood Preservation Immunology Dehydroascorbic acid Inflammation Mediators medicine.symptom Biomarkers Oxidative stress
Zdroj:	Scandinavian Journal of Clinical and Laboratory Investigation. 71:299-303
ISSN:	1502-7686 0036-5513
DOI:	10.3109/00365513.2011.563789
Popis:	Transfusion of blood components may increase the risk of complications in relation to surgery. During storage, red blood cells (RBCs) undergo structural and functional changes that may reduce function and viability after transfusion. The aim of the study was to evaluate the quality of buffy-coat reduced red cells in SAG-M additive solution, by assessing biomarkers of oxidative and inflammatory stress during a storage period of 35 days.Ten units of RBCs were stored for 35 days. Samples were collected from the units at storage days 1, 3, 7, 14, 21, 28 and 35, respectively. The samples were analysed for various biomarkers expressing the oxidative stress and inflammation, including malondialdehyde (MDA), α-tocopherol (AT), dehydroascorbic acid (DHA), ascorbate (ASC), YKL-40 and interleukin-6 (IL-6).The levels ofMDA, ASC, DHA, IL-6 and YKL-40 changed significantly during the storage period (p0.001, p0.001, p0.001, p = 0.004 and p0.001 respectively). A significant change in AT levels could not be shown (p = 0.087).RBCs displayed significant changes in all measured indices of oxidative and inflammatory stress during a storage period of 35 days except for AT. The data suggest a possible rationale behind the observation that aging blood products may increase the risk of complications following surgery and blood transfusion.
Databáze:	OpenAIRE
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