Neurophysiological evaluation of zidovudine in asymptomatic HIV-1 infection: a longitudinal placebo-controlled study
| Autor: | Jose Catalan, David Hawkins, Adrian Burgess, Gillian Irving, John Gruzelier, Torsten Baldeweg, Massimo Riccio, Janet Stygall, S. Catt |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Placebo-controlled study HIV Infections Neuropsychological Tests Electroencephalography Antiviral Agents Asymptomatic Zidovudine Double-Blind Method Acquired immunodeficiency syndrome (AIDS) Internal medicine HIV Seropositivity Humans Medicine Longitudinal Studies medicine.diagnostic_test business.industry Neuropsychology Quantitative electroencephalography medicine.disease CD4 Lymphocyte Count Surgery Neurology Cohort Evoked Potentials Auditory HIV-1 Evoked Potentials Visual Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Journal of the Neurological Sciences. 132:162-169 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/0022-510x(95)00140-w |
| Popis: | The effect of early antiretroviral medication with zidovudine on neurophysiological functions was evaluated in subjects with asymptomatic HIV-1 infection. Patients were recruited participants of a larger double-blind randomised placebo-controlled treatment trial with zidovudine (Concorde). The main outcome measures included: quantitative electroencephalography (QEEG), auditory event-related potentials (AEP) and pattern-reversal visual evoked potentials (PRVEP), as well as standard clinical, virological and immunological markers. No significant impairment and no difference between treatment groups was found in visual P100 latency and auditory long-latency P3 responses which is in agreement with the absence of neurological and neuropsychological impairment over the study period. Significant treatment effects were revealed by quantitative electroencephalography (QEEG). While the placebo group showed a significant increase in delta and theta slow frequency QEEG activity over the study period, slow wave amplitude remained unchanged in the zidovudine group after a mean follow-up period of 28 months. In summary, the data provide evidence for a low level neuropathological process in asymptomatic HIV-1 infection which can be effectively suppressed by antiretroviral medication. |
| Databáze: | OpenAIRE |
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