Pathological Characteristics of Prostate Cancer in Elderly Men
| Autor: | Gustavo de la Roza, Richard F. Jones, Vishal S. Chandan, Nicolas Barry Delongchamps, Gabriel P. Haas, Mary Jumbelic, Ching Y. Wang, Gregory Threatte |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Urology Autopsy Young Adult Prostate cancer Prostate Internal medicine medicine Humans Young adult Pathological Aged Aged 80 and over Gynecology Genitourinary system business.industry Age Factors Prostatic Neoplasms Cancer Middle Aged medicine.disease Prostate-specific antigen medicine.anatomical_structure business |
| Zdroj: | Journal of Urology. 182:927-930 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/j.juro.2009.05.018 |
| Popis: | Recent guidelines recommend that men older than 75 years should not be screened for prostate cancer. However, increased life expectancy and the development of less invasive treatments have led to an interest in characterizing prostate cancer in elderly men. We determined how prostate cancer pathological characteristics differ in men older vs younger than 70 years.We studied differences in prostate cancer pathological characteristics in autopsied glands from men 70 years old or older and compared findings to those in men younger than 70 years. All men died of causes unrelated to prostate cancer. Prostates were whole mounted at 4 mm intervals. Histological analysis was done to identify and characterize each cancer focus observed. Tumor volume was measured by computerized planimetry. Cancer was defined as clinically significant or insignificant based on established histological characteristics.Of 211 prostates evaluated 74 were from men 70 years old or older. We identified cancer in 33 men (45%) in this age group vs in 26 of 137 (19%) younger than 70 years (p0.001). Men older than 70 years had significantly larger cancer and more clinically significant cancer (64% vs 23%, p0.005). Older men had more advanced stage cancer and greater Gleason scores (p0.001).In an autopsy study of men with no history of prostate cancer those older than 70 years were more likely to have larger and higher grade prostate cancer than younger men. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|