Long-Distance Transportation of Carbon Monoxide–Poisoned Patients on Extracorporeal Membrane Oxygenation Seems Possible:A Porcine Feasibility Study
| Autor: | Carsten Simonsen, Benedict Kjærgaard, Jan Jesper Andreasen, Sigridur Olga Magnusdottir, René Christian Bleeg, Claus Lie |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Time Factors
Swine medicine.medical_treatment 030204 cardiovascular system & hematology Emergency Nursing Carbon Monoxide Poisoning 03 medical and health sciences chemistry.chemical_compound Extracorporeal Membrane Oxygenation 0302 clinical medicine Fixed wing Extracorporeal membrane oxygenation Animals Medicine Respiratory function Oxygen content business.industry 030208 emergency & critical care medicine Air Ambulances CO poisoning Heart Arrest surgical procedures operative chemistry Anesthesia Carboxyhemoglobin Emergency Medicine Feasibility Studies Arterial blood Female Blood Gas Analysis Cardiopulmonary insufficiency business |
| Zdroj: | Simonsen, C, Magnusdottir, S O, Andreasen, J J, Bleeg, R C, Lie, C & Kjærgaard, B 2019, ' Long-Distance Transportation of Carbon Monoxide–Poisoned Patients on Extracorporeal Membrane Oxygenation Seems Possible : A Porcine Feasibility Study ', Air Medical Journal, vol. 38, no. 3, pp. 178-182 . https://doi.org/10.1016/j.amj.2019.03.009 |
| DOI: | 10.1016/j.amj.2019.03.009 |
| Popis: | Objective Extracorporeal membrane oxygenation (ECMO) has been widely used to stabilize patients with impairment of cardiac/respiratory function, and ECMO has been used to stabilize cardiopulmonary insufficiency caused by carbon monoxide (CO) poisoning in a porcine model. Airborne transportation in fixed wing aircraft of patients suffering from CO poisoning is challenging because as the air pressure drops, the oxygen content falls correspondingly. The aim of this study was to show the feasibility of cannulating and establishing ECMO therapy during airborne transportation after severe CO poisoning in a porcine model. Methods An anesthetized pig was subjected to severe CO poisoning and loaded onto a Hercules aircraft. Cardiac arrest was induced at an altitude of 8,000 feet, after which cannulation and the establishment of venoarterial (VA) ECMO were performed. Vital signs were monitored, and arterial blood samples were analyzed while airborne. Results CO poisoning was induced with carboxyhemoglobin at 58% before takeoff. We successfully cannulated the animal in-flight during cardiac arrest and initiated VA ECMO. The animal regained spontaneous circulation and was successfully weaned from ECMO. During VA ECMO, PaO2 was maintained at high levels (420-615 mm Hg). Conclusion It is possible to cannulate and initiate VA ECMO treatment as airborne en route therapy for cardiac arrest and severe CO intoxication in a porcine model. |
| Databáze: | OpenAIRE |
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