The importance of the margin of resection and radiotherapy in retroperitoneal liposarcoma
Autor: | Sujay Kulshrestha, Corinne Bunn, Patrick Sweigert, Michael J. Littau, Sonya P. Agnew, Marshall S. Baker, Fred A. Luchette |
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Rok vydání: | 2021 |
Předmět: |
Male
medicine.medical_specialty Databases Factual medicine.medical_treatment Liposarcoma Article Resection 03 medical and health sciences 0302 clinical medicine medicine Humans Retroperitoneal liposarcoma Retroperitoneal Neoplasms 030212 general & internal medicine Aged Proportional Hazards Models Retrospective Studies business.industry Proportional hazards model Margins of Excision Cancer General Medicine Middle Aged medicine.disease Neoadjuvant Therapy Survival Rate Radiation therapy Treatment Outcome 030220 oncology & carcinogenesis Female Radiotherapy Adjuvant Surgery Radiology Positive Surgical Margin business Adjuvant |
Zdroj: | Am J Surg |
ISSN: | 0002-9610 |
Popis: | BACKGROUND: Prior studies evaluating the impact of adjuvant or neoadjuvant radiotherapy on clinical outcomes in retroperitoneal liposarcoma have been underpowered. METHODS: We queried the National Cancer Database for patients undergoing resection of retroperitoneal liposarcoma from 2004 to 2016. Cox proportional hazards modeling stratified by tumor size was used to identify factors associated with overall survival. RESULTS: 4018 patients met inclusion criteria. 251 had small (10 cm) tumors. Positive surgical margins were correlated with risk of death across all tumor size categories (10 cm HR 1.30, CI [1.12, 1.51]). Adjuvant radiotherapy was associated with improved survival for patients with large tumors only (HR 0.75, CI [0.64, 0.89]). CONCLUSIONS: In retroperitoneal liposarcoma, adjuvant radiation is associated with improved survival only for patients with tumors larger than 10 cm. Radiation should be used sparingly in patients with smaller tumors. SUMMARY: The use of radiotherapy in the management of retroperitoneal sarcoma remains controversial. We isolated retroperitoneal liposarcomas only and identified a survival benefit from radiotherapy treatment only in tumors larger than 10 cm and only in the adjuvant setting. |
Databáze: | OpenAIRE |
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