Diagnosing atopic dermatitis in infancy using established diagnostic criteria: a cohort study

Autor: Knut Rudi, Petter Gjersvik, G. Hedlin, Håvard Ove Skjerven, Riyas Vettukattil, Marissa LeBlanc, Anne Catherine Staff, Linn Landrø, Eva Maria Rehbinder, K. C. Lødrup Carlsen, Guttorm Haugen, Kim M Advocaat Endre, Cilla Söderhäll, Christine M. Jonassen, Björn Nordlund
Rok vydání: 2022
Předmět:
Zdroj: British Journal of Dermatology
ISSN: 1365-2133
0007-0963
DOI: 10.1111/bjd.19831
Popis: Summary Background Diagnosing atopic dermatitis (AD) in infants is challenging. Objectives To determine the incidence and persistence of eczema and AD in infants using the UK Working Party (UKWP) and Hanifin and Rajka (H&R) criteria. Methods A cohort of 1834 infants was examined clinically at 3, 6 and 12 months of age. AD was diagnosed by UKWP (3, 6 and 12 months) and H&R (12 months) criteria. Logistic regression models were used to assess the relationship between AD and eczema. Results Eczema was observed in 628 (34·2%) infants (n = 240, n = 359 and n = 329 at 3, 6 and 12 months, respectively), with AD diagnosed in 212 (33·7%) infants with any eczema and in 64/78 (82%) infants with eczema at all three visits. The odds of AD were lower with first presentation of eczema at 6 [odds ratio (OR) 0·33, 95% confidence interval (CI) 0·22–0·48] or 12 months (OR 0·49, 95% CI 0·32–0·74) than at 3 months, and higher in infants with eczema at three (OR 23·1, 95% CI 12·3–43·6) or two (OR 6·5, 95% CI 4·3–9·9) visits vs. one visit only. At 12 months, 156/329 (47·4%) fulfilled the UKWP and/or H&R criteria; 27 (8%) fulfilled the UKWP criteria only and 65 (20%) only the H&R criteria. Of the 129 infants who fulfilled the H&R criteria, 44 (34·1%) did not meet the itch criterion. Conclusions Used in combination and at multiple timepoints, the UKWP and H&R criteria for AD may be useful in clinical research but may have limited value in most other clinical settings.
Databáze: OpenAIRE
Externí odkaz: