Principal Strain Vascular Elastography: Simulation and Preliminary Clinical Evaluation
| Autor: | Marvin M. Doyley, Rohit Nayak, Giovanni Schifitto, Steven J. Huntzicker, Vikram S. Dogra, Nancy Carson, Jacques Ohayon |
|---|---|
| Přispěvatelé: | Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Polytech Annecy-Chambéry (EPU [Ecole Polytechnique Universitaire de l'Université de Savoie]), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Department of Pediatrics (OTTAWA - Pedia), University of Ottawa [Ottawa], Department of Electrical and Computer Engineering, University of Rochester [USA], Usson, Yves |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Acoustics and Ultrasonics Plane wave imaging [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging MESH: Muscle Contraction MESH: Rabbits Pilot Projects MESH: Actomyosin 01 natural sciences 030218 nuclear medicine & medical imaging 0302 clinical medicine Reference Values Transverse isotropy Image Processing Computer-Assisted MESH: Animals Anisotropy 010301 acoustics Radiological and Ultrasound Technology medicine.diagnostic_test Strain (chemistry) Fibrous cap Middle Aged Carotid Arteries medicine.anatomical_structure Elasticity Imaging Techniques Polar Female Elastography Principal strain Materials science Biophysics Vascular elastography MESH: Actins Article 03 medical and health sciences Optics 0103 physical sciences medicine Humans Computer Simulation Radiology Nuclear Medicine and imaging Aged business.industry Isotropy Reproducibility of Results MESH: Myosins Atherosclerosis [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging business Biomedical engineering |
| Zdroj: | Ultrasound in Medicine & Biology Ultrasound in Medicine & Biology, Elsevier, 2017, pp.616-26 |
| ISSN: | 0301-5629 |
| Popis: | It is difficult to produce reliable polar strain elastograms (radial and circumferential) because the center of carotid artery is typically unknown. Principal strain imaging can overcome this limitation, but suboptimal lateral displacement estimates measured with conventional ultrasonic imaging methods make this an impractical approach for visualizing the mechanical properties within the carotid artery. We hypothesize that compounded plane wave imaging can minimize this problem. To corroborate this hypothesis, we performed (a) simulations with vessels of varying morphology and mechanical behavior (i.e., isotropic and transversely isotropic), and (b) a pilot study with 10 healthy volunteers. The accuracy of principal and polar strain (computed using knowledge of the precise vessel center) elastograms varied between 7–17%. In both types of elastograms, strain concentrated at the junction between the fibrous cap and the vessel wall, and the strain magnitude decreased with increasing fibrous cap thickness. Elastograms obtained from healthy volunteers were consistent with those obtained from transversely isotropic homogeneous vessels; they were spatially asymmetric–a trend that was common to both principal and polar strains. No significant differences were observed in the mean strain recovered from principal and polar strains (p > 0.05). This investigation demonstrates that principal strain elastograms measured with compounding plane wave imaging overcame problems incurred when polar strain elastograms are computed with imprecise estimates of the vessel center. |
| Databáze: | OpenAIRE |
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