The Treatment of Benign Hypertension with Clonidine
| Autor: | Kellett Rj, Hamilton M |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Adult
Male Benign hypertension Physical Exertion Posture 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine medicine Humans Antihypertensive Agents Aged Aniline Compounds business.industry Imidazoles General Medicine Middle Aged medicine.disease Clonidine 030220 oncology & carcinogenesis Anesthesia Hypertension Female Methyldopa business medicine.drug |
| Zdroj: | Scottish Medical Journal. 15:137-142 |
| ISSN: | 2045-6441 0036-9330 |
| DOI: | 10.1177/003693307001500403 |
| Popis: | Clonidine (Catapres) is a new drug for the treatment of hypertension which has an uncertain mode of action. Sixty-one patients have been treated with Clonidine for up to 21 months. Side-effects of treatment have been troublesome and in 20 per cent of patients have necessitated discontinuing therapy. Sedation was the most frequent and troublesome side-effect. Dryness of the mouth was a less troublesome symptom. In only 48 per cent of patients continuing Clonidine was good blood pressure control achieved and maintained. In a comparable group of patients treated with Methyl Dopa only 7 per cent had to discontinue therapy because of side-effects of the drug, and effective control was achieved in 70 per cent of the remainder. Clonidine is strikingly devoid of postural and exercise hypotensive effects, and produces a uniform control of blood pressure throughout the day. It has been successfully combined with Methyl Dopa and Bethanidine. Despite its troublesome side-effects, these attributes may make it a satisfactory drug for the treatment of patients in whom uniform control is difficult. |
| Databáze: | OpenAIRE |
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