Giardia intestinalis Glucosamine 6-Phosphate Isomerase: the Key Enzyme to Encystment Appears to be Controlled by Ubiquitin Attachment
| Autor: | Alex B Lopez, Harry van Keulen, Mohammed T Hossain |
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| Rok vydání: | 2002 |
| Předmět: |
Genes
Protozoan Isomerase medicine.disease_cause Microbiology Cell wall chemistry.chemical_compound Ubiquitin Glucosamine parasitic diseases Gene expression medicine Animals Giardia lamblia Cloning Molecular Enzyme inducer Aldose-Ketose Isomerases chemistry.chemical_classification biology Cell Differentiation DNA Protozoan Recombinant Proteins Enzyme Gene Expression Regulation chemistry Biochemistry Enzyme Induction biology.protein |
| Zdroj: | The Journal of Eukaryotic Microbiology. 49:134-136 |
| ISSN: | 1550-7408 1066-5234 |
| DOI: | 10.1111/j.1550-7408.2002.tb00356.x |
| Popis: | The cyst wall of the parasitic protozoan, Giardia intestinalis, is composed of a polymer of N-acetylgalactosamine, the precursor of which is synthesized by an inducible enzyme pathway. The first enzyme in this pathway, glucosamine 6-phosphate isomerase, is transcriptionally regulated. During encystment and in mature cysts this isomerase appears to be modified by ubiquitin attachment. Thus, it might be targeted for destruction by an ubiquitin-mediated pathway, suggesting that glucosamine 6-phosphate isomerase expression is tightly regulated. |
| Databáze: | OpenAIRE |
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