Limitations and benefits of FDG‐PET/CT in NF1 patients with nerve sheath tumors: A cross‐sectional/longitudinal study

Autor: Kunihiro Ikuta, Yoshihiro Nishida, Hiroshi Koike, Hiroshi Urakawa, Shiro Imagama, Kan Ito, Tomohisa Sakai, Shinji Ito
Rok vydání: 2021
Předmět:
Male
0301 basic medicine
Cancer Research
Longitudinal study
Carcinogenesis
Kaplan-Meier Estimate
Nerve sheath
Nerve Sheath Neoplasms
Malignant transformation
0302 clinical medicine
Positron Emission Tomography Computed Tomography
Medicine
Longitudinal Studies
Prospective Studies
Child
Benignity
Thyroid
SUVmax
General Medicine
Middle Aged
Prognosis
Magnetic Resonance Imaging
medicine.anatomical_structure
Oncology
natural history
030220 oncology & carcinogenesis
Original Article
Female
Fdg pet ct
Radiology
Adult
medicine.medical_specialty
Neurofibromatosis 1
Adolescent
Standardized uptake value
Malignancy
Young Adult
03 medical and health sciences
MPNST
Clinical Research
Fluorodeoxyglucose F18
Humans
Aged
Neurofibroma
Plexiform
business.industry
Original Articles
medicine.disease
PET
Cross-Sectional Studies
030104 developmental biology
ROC Curve
Feasibility Studies
business
plexiform neurofibroma
Zdroj: Cancer Science
ISSN: 1349-7006
1347-9032
Popis: The purposes of this study were to re‐confirm the usefulness of PET/CT in the differentiation of benignity/malignancy of neurogenic tumors in NF1 patients, and to analyze the natural course of plexiform neurofibroma (pNF) and clarify whether PET/CT is also useful for detecting tumors other than neurogenic tumors. PET/CT was prospectively imaged in 36 NF1 patients. There were 14 malignant peripheral nerve sheath tumors (MPNSTs) in 14 patients, and 54 pNFs in 30 patients. Nine patients had both MPNST and pNF. Maximal standardized uptake value (SUVmax) was significantly higher in MPNST (median 7.6: range 4.1‐10.4) (P
Analyzing 68 neurogenic tumors in NF1 patients with PET/CT, SUVmax was significantly higher in MPNST compared with that of pNF, which re‐confirmed results of previous reports from other countries. In NF1 patients, plexiform neurofibroma and MPNST co‐existed, differentiation of malignancy/benignity with SUVmax of PET/CT should be carefully evaluated. PET/CT is useful to detect lesions other than neurogenic tumors such as thyroid diseases in NF1 patients.
Databáze: OpenAIRE
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