Cross-sectional analysis of pulsatile hemodynamics across the adult life span: Reference values, healthy and early vascular aging : The Heinz Nixdorf Recall and the MultiGeneration Study
| Autor: | Amir A. Mahabadi, Karl-Heinz Jöckel, Nils Lehmann, Ulla Roggenbuck, Susanne Moebus, Thomas Weber, Bernhard Hametner, Raimund Erbel, Noreen Pundt, Siegfried Wassertheurer |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Aging Adolescent Physiology Population Pulsatile flow Medizin Hemodynamics 030204 cardiovascular system & hematology Pulse Wave Analysis 03 medical and health sciences Young Adult 0302 clinical medicine Reference Values Internal medicine Internal Medicine medicine Humans 030212 general & internal medicine education Pulse wave velocity Aorta Aged Aged 80 and over education.field_of_study business.industry Anthropometry Middle Aged Middle age Pulse pressure Cross-Sectional Studies Cohort Cardiology Female Cardiology and Cardiovascular Medicine business |
| Popis: | Background Pulsatile hemodynamics predict major cardiovascular events. We aimed to provide comprehensive population-based reference values and to compare different measures of pulsatile hemodynamics to define early vascular aging (EVA) as well as healthy vascular aging (HVA). Methods In 2721 participants from the population-based Heinz Nixdorf Recall Study and the associated MultiGeneration Study, free from diabetes, cardiovascular disease, and antihypertensive drugs, we performed high-fidelity radial tonometry, calibrated waveforms with brachial blood pressures and processed them with a validated transfer function, pulse wave analysis, and wave separation analysis. Aortic pulse wave velocity (aoPWV) was estimated with a validated regression formula. HVA was defined as the lowest, EVA as the highest age-specific decile of central pulse pressure (cPP), backward wave amplitude, and aoPWV. Results Overall, 56.4% of participants were female, age range 18-90 years. Brachial PP increased from middle age, whereas cPP increased across the entire adult life span. Wave reflections increased across all age groups, apart from a plateau in older male participants. Indices of wave reflection were higher in women than in men. AoPWV showed the most prominent rise with age in both sexes. EVA and HVA, defined by cPP and backward wave amplitude, differed mainly by hemodynamic variables. In contrast, EVA participants were characterized by a worse hemodynamic, anthropometric, metabolic, and inflammatory profile, if aoPWV was used to discriminate EVA and HVA. Conclusion Age-specific and sex-specific reference values for central pulsatile hemodynamics in a general white population cohort are provided and may be utilized to define HVA and EVA. |
| Databáze: | OpenAIRE |
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