Optimal Configuration of Proton-Therapy Accelerators for Relative-Stopping-Power Resolution in Proton Computed Tomography
| Autor: | Alexander T. Herrod, Alasdair Winter, Serena Psoroulas, Tony Price, Hywel L. Owen, Robert B. Appleby, Nigel Allinson, Michela Esposito |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Herrod, A T, Winter, A, Psoroulas, S, Price, T, Owen, H L, Appleby, R B, Allinson, N & Esposito, M 2022, ' Optimal Configuration of Proton-Therapy Accelerators for Relative-Stopping-Power Resolution in Proton Computed Tomography ', Physical Review Applied, vol. 18, no. 1, 014020 . https://doi.org/10.1103/PhysRevApplied.18.014020 |
| ISSN: | 2331-7019 |
| DOI: | 10.1103/physrevapplied.18.014020 |
| Popis: | The determination of relative stopping power (RSP) via proton computed tomography (pCT) of a patient is dependent in part on the knowledge of the incoming proton kinetic energies; the uncertainty in these energies is in turn determined by the proton source—typically a cyclotron. Here, we show that reducing the incident proton beam energy spread may significantly improve RSP determination in pCT. We demonstrate that the reduction of beam energy spread from the typical 1.0% (at 70 MeV) down to 0.2% can be achieved at the proton currents needed for imaging at the Paul Scherrer Institut 250-MeV cyclotron. Through a simulated pCT imaging system, we find that this effect results in RSP resolutions as low as 0.2% for materials such as cortical bone, up to 1% for lung tissue. Several materials offer further improvement when the beam (residual) energy is also chosen such that the detection mechanisms used provide the optimal RSP resolution. |
| Databáze: | OpenAIRE |
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