Impaired natural killer cell counts and cytolytic activity in patients with severe COVID-19
| Autor: | Arabesque Parker, Jan Storek, Poonam Dharmani-Khan, Meer Taher Shabani-Rad, Minal Borkar Tripathi, Wendy I. Sligl, Faisal Khan, Jan Willem Cohen Tervaert, Rehan M. Faridi, Amit Kalra, Mohammed Osman |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Cytotoxicity Immunologic Male Adolescent Immunobiology and Immunotherapy Pneumonia Viral Inflammation Disease macromolecular substances Severity of Illness Index Proinflammatory cytokine Natural killer cell 03 medical and health sciences Betacoronavirus Young Adult 0302 clinical medicine medicine Humans Lymphocyte Count Pandemics Aged business.industry SARS-CoV-2 musculoskeletal neural and ocular physiology Interleukins Interleukin-2 Receptor alpha Subunit Interleukin COVID-19 Hematology Middle Aged medicine.disease Killer Cells Natural Cytolysis 030104 developmental biology medicine.anatomical_structure nervous system Immunology Interleukin 12 Female medicine.symptom Cytokine storm business Coronavirus Infections 030217 neurology & neurosurgery |
| Zdroj: | Blood Advances |
| ISSN: | 2473-9537 |
| Popis: | Key Points NK-cell levels and activity are impaired in severe COVID-19 patients. Reduced NK-cell activity, elevated sCD25, and hyperferritinemia are indicative of immune dysregulation in severe COVID-19. The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–driven coronavirus disease 2019 (COVID-19) has caused unprecedented human death and has seriously threatened the global economy. Early data suggest a surge in proinflammatory cytokines in patients with severe COVID-19, which has been associated with poor outcomes. We recently postulated that the inflammatory response in patients with severe COVID-19 disease is not inhibited by natural killer (NK) cells, resulting in a “cytokine storm.” Here, we assessed the NK-cell functional activity and the associated cytokines and soluble mediators in hospitalized COVID-19 patients. Significantly impaired NK-cell counts and cytolytic activity were observed in COVID-19 patients when compared with healthy controls. Also, cytokines like interleukin 12 (IL12), IL15, and IL21 that are important for NK-cell activity were not detected systematically. Serum concentrations of soluble CD25 (sCD25)/soluble IL2 receptor α (sIL2-Rα) were significantly elevated and were inversely correlated with the percentage of NK cells. Impaired NK-cell cytolytic activity together with other laboratory trends including elevated sCD25 were consistent with a hyperinflammatory state in keeping with macrophage-activation syndrome. Our findings suggest that impaired counts and cytolytic activity of NK cells are important characteristics of severe COVID-19 and can potentially facilitate strategies for immunomodulatory therapies. Visual Abstract |
| Databáze: | OpenAIRE |
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