| Autor: |
Lisa N. Steele, Natalie Z. Cvijanovich, David Finkelstein, J. Dean Jarvis, Vicki L. Montgomery, Brooke B. Park, Matthew L. Paden, Chee-Chee Manghram, Judi Arnold, Yu Zhang, Juliane Bubeck Wardenburg, Anna A. Agan, Kristin Greathouse, Marc-André Dugas, Ronald C. Sanders, Stephanie Osborne, Eloise Lemon, E.K. Allen, Rachel Jacobs, Angela Czaja, Katri Typpo, Sherell Thornton-Thompson, L. Eugene Daugherty, Philippe Jouvet, Stephanie Meisner, Angela A. Doucette, Kara Richardson, Sandra B. Lindahl, Jillian Egan, Melania Bembea, Laurel Baglia, Mary E. Hartman, Scott L. Weiss, Healther Anthony, Megan Brocato, Tracy Evans, Aimee Labell, Michael Kiers, Carrie M. Rosenberger, Susanna Burr, Stephanie Huston, Adam Schwarz, Frederick E. Barr, Cheryl L. Stone, Mary Ann Diliberto, Nancy Jaimon, Ashely L. Ortiz, Jenny L. Bush, Maureen Convery, Mark W. Hall, Monroe Carell, Chisom Onwunyi, Courtney Bliss, Shivan Shetty, Ramon Adams, Anne-Marie Fontaine, Ana Lia Graciano, Machelle Dawson, Neal J. Thomas, Danielle Liss, Peter M. Mourani, Marita Thompson, Martha Sisko, Anil Sapru, Barry P. Markovitz, Tiffany Patterson, Kate Luther, Victoria Lo, Grace Yoon, Stephanie A. Ash, Tushar Bhangale, Robin L. Kelly, Elizabeth D. White, Erin Zielinski, Renee A. Higgerson, Glenda Hefley, Jen Deschenes, Kate G. Ackerman, Chhavi Katyal, Mark A. Helfaer, Ryan Nofziger, Melita Baldwin, LeeAnn M. Christie, Paul G. Thomas, John S. Giuliano, Briana E. Horn, Stephen C. Kurachek, Douglas F. Willson, Ryan M. Sullivan, Kate Sewell, Edward J. Truemper, Julie C. Fitzgerald, Jill Raymond, Avani Shukla, Valeri Batara Aymami, Gwenn E. McLaughlin, Julie Simon, Helen C. Su, Kathleen A. Sala, Christopher L. Carroll, Ursula Kyle, Heidi R. Flori, Shannon M. Keisling, Rainer Gedeit, Debra Spear, Andrea C. DeDent, Joana Tala, Rich Toney, Kathy Murkowski, Ellen M. Smith, Yamila Sierra, Nick Anas, Bria M. Coates, Emily Jewett, Peter Mourani, Christine Traul, Adrienne G. Randolph, Allan Doctor, Jeff Terry, Lisa Petersen, Daniel L. Levin, Danielle Loyola, David Tellez, Michele Kong, Steve Shein, Becky Brumfield, Rica Sharon P. Morzov, Laura Loftis, Wai-Ki Yip, Susan Bergant, Ofelia Vargas-Shiraishi |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
The Journal of infectious diseases. 216(1) |
| ISSN: |
1537-6613 |
| Popis: |
Background Interferon-induced transmembrane protein 3 (IFITM3) restricts endocytic fusion of influenza virus. IFITM3 rs12252_C, a putative alternate splice site, has been associated with influenza severity in adults. IFITM3 has not been evaluated in pediatric influenza. Methods The Pediatric Influenza (PICFLU) study enrolled children with suspected influenza infection across 38 pediatric intensive care units during November 2008 to April 2016. IFITM3 was sequenced in patients and parents were genotyped for specific variants for family-based association testing. rs12252 was genotyped in 54 African-American pediatric outpatients with influenza (FLU09), included in the population-based comparisons with 1000 genomes. Splice site analysis of rs12252_C was performed using PICFLU and FLU09 patient RNA. Results In PICFLU, 358 children had influenza infection. We identified 22 rs12252_C homozygotes in 185 white non-Hispanic children. rs12252_C was not associated with influenza infection in population or family-based analyses. We did not identify the Δ21 IFITM3 isoform in RNAseq data. The rs12252 genotype was not associated with IFITM3 expression levels, nor with critical illness severity. No novel rare IFITM3 functional variants were identified. Conclusions rs12252 was not associated with susceptibility to influenza-related critical illness in children or with critical illness severity. Our data also do not support it being a splice site. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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