Micrococcus luteus cells and cell walls induce anaphylactoid reactions accompanied by early death and serum cytokines in mice primed with muramyl dipeptide
| Autor: | Haruhiko Takada, Toshihiko Monodane, Yoshihiro Kawabata |
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| Rok vydání: | 1997 |
| Předmět: |
Microbiology (medical)
Male Micrococcaceae Ratón medicine.medical_treatment Immunology Microbiology chemistry.chemical_compound Mice Cell Wall medicine Immunology and Allergy Animals Interleukin 6 Anaphylaxis Mice Inbred C3H biology Interleukin-6 Tumor Necrosis Factor-alpha General Medicine biology.organism_classification Micrococcus luteus Infectious Diseases Cytokine chemistry Injections Intravenous biology.protein bacteria Cytokines Tumor necrosis factor alpha Female Peptidoglycan Acetylmuramyl-Alanyl-Isoglutamine Muramyl dipeptide |
| Zdroj: | FEMS immunology and medical microbiology. 17(1) |
| ISSN: | 0928-8244 |
| Popis: | Micrococcus luteus strains at a dose of 500 microg of whole cells caused anaphylactoid reactions leading to death in some instances within 1 h in C3H/HeN mice primed with muramyl dipeptide (MDP, 100 microg). Tumor necrosis factor (TNF) and interleukin-6 (IL-6) were induced in the serum of half and of all the surviving mice, respectively. Cell wall specimens of M. luteus so far examined also caused anaphylactoid reactions accompanied by early death and one strain induced high levels of TNF and IL-6. Cytoplasmic membranes also induced IL-6. Essentially similar results were obtained with representative M. luteus cells and a cell wall specimen in MDP-primed C3H/HeJ mice. These results indicate that M. luteus has virulence activities that are associated with the induction of septic shock and systemic inflammatory diseases. |
| Databáze: | OpenAIRE |
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