Nociceptive laser-evoked brain potentials do not reflect nociceptive-specific neural activity
| Autor: | Gian Domenico Iannetti, André Mouraux |
|---|---|
| Přispěvatelé: | UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - MD/FSIO - Département de physiologie et pharmacologie |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Time Factors Laser-Evoked Potentials Physiology Electroencephalography - methods Pain - physiopathology Pain Electroencephalography Stimulus (physiology) Somatosensory system Brain mapping Young Adult Stimulus modality Evoked Potentials Somatosensory medicine Psychophysics Humans Pain Measurement Evoked Potentials Somatosensory - physiology Brain Mapping medicine.diagnostic_test General Neuroscience Lasers Nociceptors Nociception Acoustic Stimulation Nociceptor Linear Models Female Psychology Pain Measurement - methods Neuroscience Algorithms Photic Stimulation Nociceptors - physiology Lasers - adverse effects |
| Zdroj: | Journal of Neurophysiology, Vol. 101, no.6, p. 3258-69 (2009) Journal of Neurophysiology, Vol. 101, no. 6, p. 3258-3269 (2009) |
| Popis: | Brief radiant laser pulses can be used to activate cutaneous Aδ and C nociceptors selectively and elicit a number of transient brain responses [laser-evoked potentials (LEPs)] in the ongoing EEG. LEPs have been used extensively in the past 30 years to gain knowledge about the cortical mechanisms underlying nociception and pain in humans, by assuming that they reflect at least neural activities uniquely or preferentially involved in processing nociceptive input. Here, by applying a novel blind source separation algorithm (probabilistic independent component analysis) to 124-channel event-related potentials elicited by a random sequence of nociceptive and non-nociceptive somatosensory, auditory, and visual stimuli, we provide compelling evidence that this assumption is incorrect: LEPs do not reflect nociceptive-specific neural activity. Indeed, our results indicate that LEPs can be entirely explained by a combination of multimodal neural activities (i.e., activities also elicited by stimuli of other sensory modalities) and somatosensory-specific, but not nociceptive-specific, neural activities (i.e., activities elicited by both nociceptive and non-nociceptive somatosensory stimuli). Regardless of the sensory modality of the eliciting stimulus, the magnitude of multimodal activities correlated with the subjective rating of saliency, suggesting that these multimodal activities are involved in stimulus-triggered mechanisms of arousal or attentional reorientation. |
| Databáze: | OpenAIRE |
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