Molecular evidence of HTLV-II subtype B among an urban population living in South Brazil

Autor: Jomar Pereira Laurino, Jane Dagmar Pollo Renner, Virgínia Minghelli Schmitt, Márcio Menna-Barreto
Rok vydání: 2006
Předmět:
Male
Urban Population
viruses
Immunology
Population
Blotting
Western
Molecular Sequence Data
Blood Donors
Enzyme-Linked Immunosorbent Assay
Urban area
Polymerase Chain Reaction
Evolution
Molecular
immune system diseases
Phylogenetics
Seroepidemiologic Studies
hemic and lymphatic diseases
Virology
Genetic variation
Humans
education
Phylogeny
geography
education.field_of_study
Molecular Epidemiology
geography.geographical_feature_category
Phylogenetic tree
Traditional medicine
biology
Molecular epidemiology
Base Sequence
Sequence Analysis
RNA
Human T-lymphotropic virus 2
Terminal Repeat Sequences
virus diseases
Genetic Variation
Nucleic acid amplification technique
Emigration and Immigration
biology.organism_classification
Deltaretrovirus
Infectious Diseases
HTLV-II Infections
RNA
Viral
Female
Nucleic Acid Amplification Techniques
Brazil
Demography
Zdroj: AIDS research and human retroviruses. 22(4)
ISSN: 0889-2229
Popis: Human T cell lymphotropic virus type II (HTLV-II) is a deltaretrovirus endemic in Indian populations living in Central and South America, among Pygmies tribes from Central Africa, and epidemic among injecting drug users (IDUs) in the United States, Europe, Southeast Asia, and South America. To date only the HTLV-IIa subtype has been demonstrated among Brazilians (Amazon basin Indians, blood donors, and IDUs). We analyzed HTLV-II isolates from 12 individuals living in the urban area of Porto Alegre, Southern Brazil, identified as seropositive for HTLVI/II in a blood donation. The HTLV-II long terminal repeat (LTR) region was sequenced and compared with nucleotide sequences of isolates HTLV-IIa (Mo), HTLV-IIb (NRA) prototypes. Phylogenetic analysis of the LTR region demonstrated that seven new isolates clustered together with American Indians HTLV-IIb isolates, and five new HTLV-IIa isolates clustered within the HTLV-IIa Brazilian subgroup, named the HTLV-IIc subtype. Both HTLV-IIa and IIb seem to be endemic in the urban area of Porto Alegre, South of Brazil, and could have reached this region via the Amazon basin and the Pacific Coast ancient human migratory pathways. To our knowledge this is the first study demonstrating the presence of HTLV-IIb among the urban population in Brazil.
Databáze: OpenAIRE
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