THE RELATIONSHIP BENVEEN REGIONAL BLOOD FLOW AND ABSORPTION OF LIGNOCAINE
| Autor: | Raymond G. Morris, Alex Karatassas, Anthony H. Slavotinek |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Epinephrine
Dose Injections Intramuscular Absorption Animal data Vascularity Pharmacokinetics Forelimb medicine Animals Sodium Pertechnetate Tc 99m Sheep business.industry Muscles Lidocaine General Medicine Blood flow medicine.disease Hindlimb Disease Models Animal Regional Blood Flow Concomitant Anesthesia Injections Intravenous Toxicity Surgery medicine.symptom business Infiltration (medical) Half-Life |
| Zdroj: | ANZ Journal of Surgery. 63:766-771 |
| ISSN: | 1445-2197 1445-1433 |
| DOI: | 10.1111/j.1445-2197.1993.tb00338.x |
| Popis: | With the increasing application of certain surgical procedures to 'day surgery' cases, there has been greater utilization of local anaesthetic agents. Such procedures are undertaken using single infiltration dosage recommendations for lignocaine, both with and without adrenaline. The present paper describes results obtained from a sheep model that considers the role of the regional blood flow of the injected site as a determinant of lignocaine absorption and resultant pharmacokinetics. The peak concentration of lignocaine in plasma following administration to two selected sites of different vascularity (as determined by a technetium99 washout method), as well as the effect of concomitant adrenaline administration, was shown to correlate with the regional blood flow to the site (rs = 0.73, P = 0.008). Extrapolating these animal data to the clinical situation suggests that larger dosages of lignocaine could be used safely for infiltration anaesthesia in regions of poor regional blood flow without posing a threat of lignocaine-induced toxicity, and that the current dosage recommendations could be modified in respect of the regional blood flow of the particular site to be infiltrated. |
| Databáze: | OpenAIRE |
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