Vaginal misoprostol as medical treatment for first trimester spontaneous miscarriage
| Autor: | Suk Wai Ngai, Yik Ming Chan, Oi Shan Tang, Pak Chung Ho |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
medicine.medical_specialty Vacuum Extraction Obstetrical Gestational sac Abortion law.invention Miscarriage Menstruation Randomized controlled trial Pregnancy law Oxytocics medicine Humans Vaginal bleeding Emergency Treatment Misoprostol Gynecology Obstetrics business.industry Rehabilitation Obstetrics and Gynecology medicine.disease Abortion Spontaneous Administration Intravaginal Pregnancy Trimester First Treatment Outcome medicine.anatomical_structure Reproductive Medicine Vagina Female Uterine Hemorrhage medicine.symptom business medicine.drug |
| Zdroj: | Human Reproduction. 16:1493-1496 |
| ISSN: | 1460-2350 |
| DOI: | 10.1093/humrep/16.7.1493 |
| Popis: | BACKGROUND: Misoprostol is effective for cervical priming prior to suction evacuation in first trimester pregnancy termination. This is the first randomized study to compare vaginal misoprostol versus expectant treatment in women presenting with spontaneous miscarriage. METHODS: Sixty women presenting with spontaneous miscarriage were recruited to the study at the Queen Mary Hospital between 1998 and 1999. They were randomized to group 1: misoprostol; and group 2: expectant management. Women in the misoprostol group received vaginal misoprostol 400 µg on days 1, 3 and 5. The expectant group was followed up according to the same schedule. Suction evacuation was performed if there was excessive bleeding or abdominal pain; or if a gestational sac was detected by transvaginal scan on day 15. RESULTS: Fifty-nine women completed the trial. Those who did not require suction evacuation up to the time of return of normal menstruation were considered to be successful. The incidence of side-effects was comparable between the two groups. Three women in the expectant group and one in the misoprostol group underwent emergency suction evacuation because of excessive bleeding. The mean duration of vaginal bleeding was similar for both groups (14.6 days in the misoprostol group versus 15.0 days in the expectant group). The successful rate in the misoprostol group was significantly higher than that of the expectant group (83.3 versus 48.3%, P < 0.05). CONCLUSION: We recommend repeated vaginal misoprostol 400 µg given on days 1, 3 and 5 as a treatment option for women with first trimester spontaneous miscarriage. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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