| Autor: |
Bong, Choon Looi, Ho, Duncun, Allen, John Carson, Lim, Gillian Si-Min, Tan, Hong-Kuang, Broekman, Birit F P, Fabila, Teddy, Reddy, Satish, Koh, Woon-Puay, Swee-Kim Tan, Josephine, Meaney, Michael, Rifkin-Graboi, Anne |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Bong, C L, Ho, D, Allen, J C, Lim, G S-M, Tan, H-K, Broekman, B F P, Fabila, T, Reddy, S, Koh, W-P, Swee-Kim Tan, J, Meaney, M & Rifkin-Graboi, A 2022, ' Early Neurodevelopmental Outcomes Following Exposure to General Anesthesia in Infancy : EGAIN, a Prospective Cohort Study ', Journal of Neurosurgical Anesthesiology . https://doi.org/10.1097/ANA.0000000000000857 |
| ISSN: |
1537-1921 |
| DOI: |
10.1097/ANA.0000000000000857 |
| Popis: |
BACKGROUND: General anesthesia (GA) is known to worsen neural outcomes in animals, but human research assessing early-life GA exposure and neurodevelopment show inconsistent findings. We investigated the effects of a single GA exposure for minor surgery on the neurodevelopment of healthy children at multiple time-points, using clinical assessments along with behavioral and neurophysiological measures rarely used in human research.METHODS: GA-exposed children were a prospective cohort of 250 full-term, healthy infants who underwent GA for minor surgery before 15 months. Nonexposed children were from a separate cohort of similar age, sex, ethnicity, and maternal education. In both cohorts, clinical measures (Bayley Scales of Infant and Toddler Development-III [BSID-III] and Child Behavior Checklist [CBCL1½-5]) were assessed at 24 months, and experimental tests (memory and attentional) and neurophysiology (event-related potentials) at 6 and 18 months.RESULTS: At 24 months, there were no differences between GA-exposed and nonexposed children in the cognitive, language, motor, and socioemotional domains of the BSDI-III; however, GA-exposed children had poorer parental-reported scores in BSID-III general adaptability (94.2 vs. 99.0 [mean difference, 4.77; 97.3% confidence interval, -9.29, -0.24]; P=0.020) and poorer internalizing behavior scores on CBCL1½-5 (52.8 vs. 49.4 [mean difference, 3.35; 97.3% confidence interval, 0.15-6.55]; P=0.021). For experimental measures, GA-exposed children showed differences in 4 tests at 6 and 18 months.CONCLUSIONS: GA-exposed children did not differ from unexposed children in cognitive, language or motor outcomes at 24 months, but exhibited poorer parent-reported behavior scores. Differences in infant behavior and neurophysiology were detected at 6 and 18 months. Neurophysiological assessments may complement clinically relevant assessments to provide greater insights into neurodevelopment following early GA exposure. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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