Relationship between cytosine-adenine repeat polymorphism of ADAMTS9 gene and clinical and radiologic severity of knee osteoarthritis

Autor: Elif Nihan Cetin, Esra Gunduz, Ozlem Cemeroglu, Kevser Gok, Mehmet Gunduz, Muradiye Acar, Hasim Cakirbay, Kadir Demircan
Rok vydání: 2016
Předmět:
Adult
Male
0301 basic medicine
Pathology
medicine.medical_specialty
ADAMTS9 Protein
Osteoarthritis
Severity of Illness Index
Gastroenterology
Cytosine
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Rheumatology
Risk Factors
Internal medicine
Severity of illness
Odds Ratio
medicine
Humans
Genetic Predisposition to Disease
Stage (cooking)
Genetic Association Studies
Aged
030203 arthritis & rheumatology
Chi-Square Distribution
Polymorphism
Genetic
business.industry
Adenine
Case-control study
Odds ratio
Middle Aged
Osteoarthritis
Knee
Prognosis
medicine.disease
Logistic Models
Phenotype
030104 developmental biology
chemistry
Case-Control Studies
Multivariate Analysis
Disease Progression
Female
business
Chi-squared distribution
Body mass index
Microsatellite Repeats
Zdroj: International Journal of Rheumatic Diseases. 21:821-827
ISSN: 1756-1841
DOI: 10.1111/1756-185x.12849
Popis: Objective The aim of this study is to determine the role of cytosine-adenine (CA) micro-satellite repeat sequence of ADAMTS9 gene on the development and progression of osteoarthritis (OA). Methods A total of 110 participants, including those with primary knee OA and healthy controls were enrolled in the study. Patients were stratified into two groups using the Kellgren–Lawrence staging (K–L staging) as group 1 for controls and mild OA and group 2 for moderate and severe OA. Genetic analyses were performed to determine the CA repeat length in ADAMTS9 gene. Results Twenty CA repeats were found to be statistically significant for differentiating groups 1 and 2 (P = 0.020). Age was the most significant risk factor involved, followed by ≥ 20 CA repeats and body mass index (P < 0.05). CA repeat length of ≥ 20 showed a 6.1-fold increase in probability for having OA at stage 3 or 4 compared to those of CA repeat length of < 20 (P = 0.004). In conclusion, the CA repeat length of ≥ 20 has a six-fold increase in probability for having severe OA. Conclusion ADAMTS9 gene CA repeat polymorphism may be used to determine the prognosis for OA radiologic progression. Being the first in the literature reporting the CA repeat in the promotor region of ADAMTS9 gene in patients with OA, our study could be highlighted further in future research with larger sample size.
Databáze: OpenAIRE
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