In vivo study of platelet kinetics by75Se-methionine in different haematological disorders
| Autor: | Hans Peter Hebestreit, U. Kempgens, Wolfgang Quei er, Jürgen Kulinna, U. Müller, M. Mayer, Jürgen Lüber |
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| Rok vydání: | 1977 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Pathology Time Factors Platelet maturation Selenium Methionine Megakaryocyte In vivo Internal medicine Humans Medicine Platelet Mean platelet volume Multiple myeloma Aged Radioisotopes Myeloproliferative Disorders Hematology business.industry Lymphoma Non-Hodgkin Anemia Aplastic General Medicine Middle Aged medicine.disease Hematologic Diseases Leukemia Lymphoid medicine.anatomical_structure Female Bone marrow Multiple Myeloma business |
| Zdroj: | Blut. 34:31-38 |
| ISSN: | 1432-0584 0006-5242 |
| DOI: | 10.1007/bf00997036 |
| Popis: | Labeling of platelets in vivo by 75Se-methionine was performed in premalignant and malignant haematological disorders for evaluation of the kinetics of platelet maturation. The "normal" platelet maturation time (time between the injection of the isotope and maximum radioactivity of separated blood platelets) in eight non-haematological patients showing normal platelet counts was 9.1 days. A shortening of platelet maturation time of 5-7 days was observed in three of four cases with panmyelopathy (high bone marrow cellularity), in three of four cases with malignant lymphatic disorders (multiple myeloma, chronic lymphocytic leukaemia, lymphosarcoma), and in two of four cases with myeloproliferative syndromes. No correlation to the peripheral platelet counts was observed. For explanation of the premature platelet release from the bone marrow a disturbance of the megakaryocyte maturation is suggested. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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