Androgens Attenuate Vitamin D Production Induced by UVB Irradiation of the Skin of Male Mice by an Enzymatic Mechanism
| Autor: | Lee Ying, Gordon Watson, Ronald L. Horst, David Goltzman, Yingben Xue |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Ultraviolet Rays medicine.drug_class Dermatology Biology Biochemistry vitamin D deficiency Mice chemistry.chemical_compound Dehydrocholesterols Bone Density Internal medicine medicine Vitamin D and neurology Animals Cholesterol Side-Chain Cleavage Enzyme Vitamin D Molecular Biology Calcifediol Skin Sex Characteristics Osteomalacia integumentary system Cell Biology Androgen medicine.disease Mice Inbred C57BL Androgen receptor Endocrinology chemistry Receptors Androgen Androgens Female Secondary hyperparathyroidism |
| Zdroj: | Journal of Investigative Dermatology. 135(12):3125-3132 |
| ISSN: | 0022-202X |
| DOI: | 10.1038/jid.2015.297 |
| Popis: | Cutaneous exposure to UVB irradiation is an important source of vitamin D. Here, we examined sex-specific differences in cutaneous vitamin D production in mice. Both male and female mice on a vitamin D–deficient diet manifested vitamin D deficiency, with mineral abnormalities, secondary hyperparathyroidism, and osteomalacia. UVB irradiation significantly increased vitamin D levels in the skin of female mice and normalized serum 25-hydroxyvitamin D 3 and 1,25-dihydroxyvitamin D 3 levels, as well as mineral and skeletal abnormalities. However, in male mice, the vitamin D response to UVB was attenuated and mineral and skeletal abnormalities were not normalized. The vitamin D precursor, 7-dehydrocholesterol (7DHC), was significantly lower in the skin of male than female mice. This reduction was due to local androgen action in the skin as demonstrated by castration studies and skin-specific androgen receptor deletion in male mice, both of which reversed the male phenotype. Local androgen regulation in the skin of the CYP11A1 gene, which encodes a crucial enzyme that metabolizes cholesterol, 7DHC, and vitamin D, appeared to contribute to the gender differences in UVB-induced vitamin D production and to its reversal of vitamin D deficiency. Sex-specific, enzymatically regulated differences in cutaneous production of vitamin D may therefore be of importance to ensure vitamin D sufficiency. |
| Databáze: | OpenAIRE |
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