Effectiveness of lamotrigine in clinical practice: results of a retrospective population-based study

Autor: Antoine C. G. Egberts, Yechiel A. Hekster, Antoine Keyser, Willy O. Renier, C.L.P. Deckers, P.D. Knoester
Přispěvatelé: Population-based studies of drug treatment: from molecule to patient outcomes, Universiteit Utrecht, Dep Farmaceutische wetenschappen
Rok vydání: 2005
Předmět:
Adult
Male
medicine.medical_specialty
Pediatrics
Time Factors
medicine.drug_class
Epidemiology
medicine.medical_treatment
Population
Lamotrigine
Biomedische technologie en medicijnen
Farmacie/Biofarmaceutische wetenschappen (FARM)
Epilepsy
Cognitive neurosciences [UMCN 3.2]
medicine
Perception and Action [DCN 1]
Humans
Drug Interactions
education
Retrospective Studies
Ziekenhuisstructuur en organisatie van de gezondheidszorg
education.field_of_study
Triazines
business.industry
Valproic Acid
Medical record
Farmacie(FARM)
Mood stabilizer
Middle Aged
medicine.disease
Surgery
Pathogenesis and modulation of inflammation [N4i 1]
Logistic Models
Treatment Outcome
Anticonvulsant
Neurology
Tolerability
Cohort
Anticonvulsants
Female
Neurology (clinical)
Public Health
business
Functional Neurogenomics [DCN 2]
medicine.drug
Zdroj: Epilepsy Research, 65, 1-2, pp. 93-100
Epilepsy Research, 65, 93-100
ISSN: 0920-1211
Popis: Contains fulltext : 47617.pdf (Publisher’s version ) (Closed access) OBJECTIVE: Evaluation of the effectiveness of lamotrigine in a population-based cohort of epilepsy patients. METHODS: Medical charts of 360 patients treated in 37 centres in The Netherlands were reviewed. Effectiveness of lamotrigine therapy was assessed during the first year of use, with patients serving as their own controls. Effectiveness was measured by reduction in seizure frequency and retention time. RESULTS: Effectiveness could only be assessed in 165 patients; assessment in remaining patients was not possible due to various reasons, such as insufficient medical chart information. Lamotrigine was effective in 40% of patients who had been prescribed lamotrigine because of insufficient seizure control (n=112), and 14% of these 112 patients became seizure free. Duration of epilepsy, baseline seizure frequency, valproate use, drug load and number of antiepileptic drugs (AED) used were related to effectiveness of lamotrigine. In this group, 36% continued lamotrigine (LTG) throughout the first year without experiencing a >50% seizure reduction. Lamotrigine was effective in 63% of patients who received the drug because of poor tolerability of other antiepileptic drugs (n=53). DISCUSSION: Lamotrigine is an effective drug in clinical practice. Use of retention time measures only may not correctly reflect the efficacy of antiepileptic drugs.
Databáze: OpenAIRE
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