Acquisition, prevalence and clearance of type-specific human papillomavirus infections in young sexually active Indian women: A community-based multicentric cohort study

Autor:	Richard Muwonge, Partha Basu, Tarik Gheit, Devasena Anantharaman, Yogesh Verma, Neerja Bhatla, Smita Joshi, Pulikottil O Esmy, Usha Rani Reddy Poli, Anand Shah, Eric Zomawia, Surendra S Shastri, Sharmila Pimple, Priya R Prabhu, Sanjay Hingmire, Aruna Chiwate, Catherine Sauvaget, Eric Lucas, Sylla G Malvi, Maqsood Siddiqi, Subha Sankaran, Thiraviam Pillai Rameshwari Ammal Kannan, Rintu Varghese, Uma Divate, Shachi Vashist, Gauravi Mishra, Radhika Jadhav, Massimo Tommasino, M Radhakrishna Pillai, Rengaswamy Sankaranarayanan, Kasturi Jayant, Indian HPV vaccine study group
Rok vydání:	2020
Předmět:	Viral Diseases Epidemiology HPV-31 Artificial Gene Amplification and Extension Pathology and Laboratory Medicine Cervical Cancer Polymerase Chain Reaction 0302 clinical medicine Medical Conditions Prevalence Medicine and Health Sciences 030212 general & internal medicine Longitudinal Studies Papillomaviridae Cervical cancer Community based Vaccines Multidisciplinary Cancer Risk Factors Vaccination virus diseases Natural history Infectious Diseases Oncology Medical Microbiology 030220 oncology & carcinogenesis Viral Pathogens Viruses Medicine Female Sample collection Pathogens Cohort study Research Article Adult medicine.medical_specialty Human Papillomavirus Infection Adolescent Papillomaviruses Infectious Disease Control Science Sexual Behavior Urology Sexually Transmitted Diseases India Context (language use) HPV-18 Research and Analysis Methods Microbiology 03 medical and health sciences Young Adult Internal medicine medicine Humans Papillomavirus Vaccines Human papillomavirus Molecular Biology Techniques Microbial Pathogens Molecular Biology Biology and life sciences business.industry Genitourinary Infections Papillomavirus Infections Type specific Organisms Human Papillomavirus Cancers and Neoplasms medicine.disease Medical Risk Factors business DNA viruses Gynecological Tumors
Zdroj:	PLoS ONE PLoS ONE, Vol 15, Iss 12, p e0244242 (2020)
ISSN:	1932-6203
Popis:	In context of the ongoing multi-centric HPV vaccine study in India, unvaccinated married women (N = 1484) aged 18–23 years were recruited in 2012–2015 as age-matched controls to the vaccinated women and followed up yearly. We assess type-specific prevalence, natural history and potential determinants of human papillomavirus (HPV) infection in these unvaccinated women. Cervical samples were collected yearly for at least four consecutive years. A Multiplex Type-Specific E7-Based polymerase chain reaction assay was used to detect 21 HPV types. HPV prevalence was 36.4% during 6 years. Most common HPV types were 16 (6.5%) and 31 (6.1%). Highest persistence were observed for HPV 35 (62.5%) and 52 (25%). New HPV acquisition rate was 5.6/1000 person-months of observation (PMO), highest for HPV 16 (1.1/1000 PMO). Type-specific clearance rates ranged between 2.9–5.5/100 PMO. HPV 16 and/or 18 infections were 41% (95% CI 4–63%) lower among women with 2
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24d6138b87d5fc28ba61b0564fdde58 https://pubmed.ncbi.nlm.nih.gov/33373380 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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