Solubility of eflucimibe in supercritical carbon dioxide with or without a co‐solvent
| Autor: | Jean-Jacques Letourneau, Dominique Richon, Jacques Fages, Martial Sauceau, Bernard Freiss |
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| Přispěvatelé: | Poudres et procédés - Ecole des Mines Albi-Carmaux, IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Centre de Recherche Pierre Fabre (Centre de R&D Pierre Fabre), PIERRE FABRE, École des Mines de Paris |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
co‐solvent effect
General Chemical Engineering Inorganic chemistry Eflucimibe solubility 02 engineering and technology Specific interactions chemistry.chemical_compound Supercritical carbon dioxide [CHIM.GENI]Chemical Sciences/Chemical engineering 020401 chemical engineering [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering 0204 chemical engineering Physical and Theoretical Chemistry Solubility Co-solvent effect Co solvent Molecular interactions Eflucimibe Ethanol 021001 nanoscience & nanotechnology Condensed Matter Physics 3. Good health Solvent Hildebrand solubility parameter [SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology chemistry 0210 nano-technology |
| Zdroj: | Journal of Supercritical Fluids Journal of Supercritical Fluids, Elsevier, 2004, 31 (2), pp.133-140. ⟨10.1016/j.supflu.2003.11.004⟩ |
| ISSN: | 0896-8446 |
| DOI: | 10.1016/j.supflu.2003.11.004⟩ |
| Popis: | International audience; Eflucimibe is a drug, which displays hypocholesterolemic and anti‐atherosclerotic properties in animal models. The solubility of eflucimibe in supercritical carbon dioxide has been investigated with an apparatus based on an analytical open circuit method. Solubility values have been measured at 308.15 and 318.15 K in the pressure range 8‐30 MPa. Solubility appears to be an increasing function of both temperature and pressure. The two co‐solvents investigated, ethanol and dimethylsulphoxide, are found to significantly enhance the solubility. Solubility data are reported for the 308.15 K isotherm at different total pressures and different solvent/co‐solvent ratios. The observed co‐solvent effects can be explained not only by density effects, but by the effect of molecular interactions on the basis of compound solubility parameters. |
| Databáze: | OpenAIRE |
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