Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits
Autor: | Patricia Hedenqvist, Lena Olsén, Simon T. Bate, Ulf Bondesson, Raad Askar, Mikael Hedeland, Elin Manell, Elin Fredriksson |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
040301 veterinary sciences Injections Subcutaneous Analgesic Pain relief Biological Availability Body weight Injections Intramuscular 0403 veterinary science 03 medical and health sciences Pharmaceutical Sciences 0302 clinical medicine Pharmacokinetics 030202 anesthesiology Medicine Animals New zealand white NZW rabbit Cross-Over Studies lcsh:Veterinary medicine General Veterinary Buprenorphine Injection business.industry Correction 04 agricultural and veterinary sciences General Medicine Opioid pharmacokinetics Farmaceutiska vetenskaper Bioavailability Buprenorphine Analgesics Opioid Administration routes Anesthesia lcsh:SF600-1100 Administration Intravenous Female Rabbits business medicine.drug Research Article Buprenorphine bioavailability |
Zdroj: | BMC Veterinary Research, Vol 16, Iss 1, Pp 1-10 (2020) BMC Veterinary Research |
ISSN: | 1746-6148 |
Popis: | Background Buprenorphine is one of the most used analgesics for postoperative pain in rabbits. The recommended dose in rabbits (0.01–0.05 mg/kg) is the same for intravenous (IV), intramuscular (IM), and subcutaneous (SC) administration, despite lack of pharmacokinetic data. Five male and five female New Zealand White rabbits (mean ± SD body weight 3.1 ± 0.3 kg) were administered 0.05 mg/kg buprenorphine by the IV, IM and SC routes and 0.1 mg/kg by the SC route, in a cross-over design with two-week wash-out periods between treatments. Blood was collected before, and up to 8 h post buprenorphine injection, for determination of serum levels by UPHLC-MS/MS. Results The area under the time concentration curve (AUC0-t) was lower after SC (398 ± 155 ng/mL/min) than IM (696 ± 168 ng/mL/min, p p p = 0.006). The elimination half-life was longer after SC (260 ± 120 min) than after IM (148 ± 26 min, p = 0.002) as well as IV (139 ± 33 min) injection (p p = 0.022) and 165% in male rabbits (p p = 0.6), whereas it increased in the males (71 ± 23%, p = 0.008). Conclusions The lower bioavailability of 0.05 mg/kg buprenorphine after SC administration could explain the lack of efficacy seen in clinical pain studies in rabbits, using this route. For immediate pain relief, IV or IM administration is therefore be recommended, whereas SC administration may be useful to sustain analgesic serum levels, once efficient pain relief has been achieved. The current data do not support an increase in dose to compensate for the lower SC bioavailability. |
Databáze: | OpenAIRE |
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