Hybrid Reaction Systems for the Synthesis of Alkylated Compounds Based upon Cu‐Catalyzed Coupling of Radicals and Organometallic Species
| Autor: | Goki Hirata, Takashi Nishikata, Tom D. Sheppard, Yumi Murata, Kentaro Takeuchi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Olefin fiber 010405 organic chemistry Chemistry General Chemical Engineering Radical Heteroatom General Chemistry Alkylation 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Oxidative addition 0104 chemical sciences Catalysis Elimination reaction Materials Chemistry Alkyl |
| Zdroj: | The Chemical Record. 20:403-412 |
| ISSN: | 1528-0691 1527-8999 |
| DOI: | 10.1002/tcr.201900053 |
| Popis: | A transition metal catalyzed alkylation with an alkyl halide is one of the most difficult reactions to achieve, because of the difficult oxidative addition of an alkyl-halogen bond to a metal, and the tendency of the resulting alkylmetal intermediate to undergo a β-hydride elimination reaction to give an olefin. In this review, we discuss hybrid reaction systems involving Cu catalyzed combination of radicals and organometallic species, which enable facile alkylation reactions to construct C-C and C-heteroatom bonds. This paper highlights recent progress in arylation, alkenylation, alkynylation, cyclization, addition and introduction of heteroatoms via these hybrid reaction systems. |
| Databáze: | OpenAIRE |
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