Antioxidant effect of p-coumaric acid on interleukin 1-β and tumor necrosis factor-α in rats with renal ischemic reperfusion
| Autor: | Shahin Mozaffari Godarzi, Esrafil Mansouri, Behnam Gholizadeh, Armita Valizade Gorji, Seyyed Ali Mard |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Antioxidant Coumaric Acids medicine.medical_treatment Interleukin-1beta Ischemia Anti-Inflammatory Agents Renal function medicine.disease_cause Kidney lcsh:RC870-923 Antioxidants Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Random Allocation 0302 clinical medicine Internal medicine Malondialdehyde medicine Animals Kidney surgery 030304 developmental biology 0303 health sciences Glutathione Peroxidase Renal ischemia Chemistry Superoxide Dismutase Tumor Necrosis Factor-alpha Ácido p-cumárico Estrés oxidativo Acute Kidney Injury medicine.disease Catalase lcsh:Diseases of the genitourinary system. Urology Rats Oxidative Stress Endocrinology Nephrology IL-1β 030220 oncology & carcinogenesis Reperfusion Injury TNF-α Tumor necrosis factor alpha Isquemia-reperfusión renal Oxidative stress |
| Zdroj: | Nefrología (English Edition), Vol 40, Iss 3, Pp 311-319 (2020) Nefrología, Vol 40, Iss 3, Pp 311-319 (2020) |
| ISSN: | 2013-2514 |
| Popis: | Background and aims: Renal ischemia-reperfusion occurs in some clinical conditions such as kidney surgery that can leads to acute renal failure. The aim of this study was to investigate the effect of p-coumaric acid (CA) on ischemia reperfusion (I/R) injury. Methods: Thirty rats were randomly divided into five groups; control, CA (100 mg/kg), I/R, propylene glycol (10%) + I/R and CA + I/R, (n = 6 each). CA and propylene glycol were administered orally for 2 weeks. Then, the rats were subjected to bilateral renal ischemia for 45 min and followed by reperfusion for 24 h. All rats were killed and kidney function tests, tissue malondialdehyde and activity of antioxidant enzymes were determined. Histopathological evaluations were also performed. In addition, renal expression of the tumor necrosis factor-α and interleukin-1β were determined using enzyme-linked immunosorbent assay and immunohistochemistry. Results: CA significantly improved the Cr and BUN levels in CA + I/R group compared to I/R group (p |
| Databáze: | OpenAIRE |
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