Fertility of Tall Girls Treated with High-Dose Estrogen, a Dose-Response Relationship
| Autor: | A. E. J. Hendriks, Annemieke M. Boot, Joop S.E. Laven, S. L. S. Drop |
|---|---|
| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG, Pediatrics, Obstetrics & Gynecology |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Clinical Biochemistry Kaplan-Meier Estimate Ethinyl Estradiol Biochemistry Endocrinology HEIGHT Pregnancy ETHINYLESTRADIOL media_common Obstetrics Hazard ratio ORAL-CONTRACEPTIVES GROWTH Female Live birth Infertility Female Live Birth medicine.drug Adult Infertility medicine.medical_specialty STATURE Adolescent medicine.drug_class media_common.quotation_subject IN-UTERO Context (language use) Fertility SEX STEROID TREATMENT Young Adult Ethinylestradiol Internal medicine CONCEPTION Confidence Intervals medicine Humans EXPOSURE Proportional Hazards Models Analysis of Variance Dose-Response Relationship Drug business.industry Biochemistry (medical) Estrogens medicine.disease Body Height BISPHENOL-A Estrogen business |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism, 97(9), 3107-3114. ENDOCRINE SOC Journal of Clinical Endocrinology and Metabolism, 97(9), 3107-3114. Endocrine Society |
| ISSN: | 0021-972X |
| Popis: | Context: High-dose estrogen treatment to reduce final height of tall girls increases their risk for infertility in later life.Objective: The aim was to study the effect of estrogen dose on fertility outcome of these women.Design/Setting: We conducted a retrospective cohort study of university hospital patients.Patients: We studied 125 tall women aged 20-42 yr, of whom 52 women had been treated with 100 mu g and 43 with 200 mu g of ethinyl estradiol (EE) in adolescence.Main Outcomes: Time to first pregnancy, treatment for infertility, and live birth rate were measured.Results: The time to first pregnancy was increased in treated women. Of untreated women, 80% conceived within 1 yr vs. 69% of women treated with 100 mu g EE and 59% of women treated with 200 mu g EE. This trend of increased time to pregnancy with increasing estrogen dose was significant (log rank trend test, P = 0.01). Compared with untreated women, fecundability was reduced in women treated with both 100 mu g EE [hazard ratio = 0.42; 95% confidence interval (CI), 0.19-0.95] and 200 mu g EE (hazard ratio = 0.30; 95% CI, 0.13-0.72). We also observed a significant trend in the incidence of treatment for infertility with increased estrogen dose (P = 0.04). Fecundity was affected in women treated with 200 mu g EE who had reduced odds of achieving at least one live birth (odds ratio = 0.13; 95% CI, 0.02-0.81), but not in women treated with 100 mu g EE.Conclusions: We report a dose-response relationship between fertility in later life and estrogen dose used for the treatment of tall stature in adolescent girls; a higher estrogen dose is associated with increased infertility. (J Clin Endocrinol Metab 97: 3107-3114, 2012) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|