Diabetes-Associated Susceptibility to Tuberculosis: Contribution of Hyperglycemia vs. Dyslipidemia
Autor: | Stacey Bartlett, Minh Dao Ngo, Katharina Ronacher |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Microbiology (medical)
medicine.medical_specialty Tuberculosis QH301-705.5 Review Microbiology Virology Diabetes mellitus Internal medicine Epidemiology medicine Risk factor Biology (General) Mycobacterium tuberculosis triglycerides Latent tuberculosis diabetes business.industry microbiology dyslipidemia cholesterol medicine.disease Comorbidity tuberculosis hyperglycemia business Body mass index Dyslipidemia |
Zdroj: | Microorganisms, Vol 9, Iss 2282, p 2282 (2021) Microorganisms |
ISSN: | 2076-2607 |
Popis: | Diabetes is a major risk factor for tuberculosis (TB). Diabetes increases the risk of the progression from latent tuberculosis infection (LTBI) to active pulmonary TB and TB patients with diabetes are at greater risk of more severe disease and adverse TB treatment outcomes compared to TB patients without co-morbidities. Diabetes is a complex disease, characterised not only by hyperglycemia but also by various forms of dyslipidemia. However, the relative contribution of these underlying metabolic factors to increased susceptibility to TB are poorly understood. This review summarises our current knowledge on the epidemiology and clinical manifestation of TB and diabetes comorbidity. We subsequently dissect the relative contributions of body mass index, hyperglycemia, elevated cholesterol and triglycerides on TB disease severity and treatment outcomes. Lastly, we discuss the impact of selected glucose and cholesterol-lowering treatments frequently used in the management of diabetes on TB treatment outcomes. |
Databáze: | OpenAIRE |
Externí odkaz: |