Cytokine Disturbances in Coronary Artery Ectasia Do Not Support Atherosclerosis Pathogenesis
| Autor: | Zain Sharif, Usama Boles, Urban Wiklund, Siobhan McGrory, Michael Y. Henein, Anders Johansson, Santhosh David |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_treatment coronary artery ectasia atherosclerosis cytokines macrophage activation immune inflammatory response coronary artery disease 030204 cardiovascular system & hematology Pathogenesis Coronary artery disease lcsh:Chemistry 0302 clinical medicine Risk Factors Epidemiology Cardiac and Cardiovascular Systems lcsh:QH301-705.5 Spectroscopy Kardiologi General Medicine Middle Aged Coronary Vessels Computer Science Applications Cytokine Cardiology Female medicine.symptom Dilatation Pathologic medicine.medical_specialty Inflammation Models Biological Catalysis Article Inorganic Chemistry 03 medical and health sciences Internal medicine medicine Humans Physical and Theoretical Chemistry Molecular Biology Demography business.industry Organic Chemistry Coronary artery ectasia Case-control study Reproducibility of Results medicine.disease 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Case-Control Studies business |
| Zdroj: | International Journal of Molecular Sciences, Vol 19, Iss 1, p 260 (2018) International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 19; Issue 1; Pages: 260 |
| Popis: | BACKGROUND: Coronary artery ectasia (CAE) is a rare disorder commonly associated with additional features of atherosclerosis. In the present study, we aimed to examine the systemic immune-inflammatory response that might associate CAE. METHODS: Plasma samples were obtained from 16 patients with coronary artery ectasia (mean age 64.9 ± 7.3 years, 6 female), 69 patients with coronary artery disease (CAD) and angiographic evidence for atherosclerosis (age 64.5 ± 8.7 years, 41 female), and 140 controls (mean age 58.6 ± 4.1 years, 40 female) with normal coronary arteries. Samples were analyzed at Umeå University Biochemistry Laboratory, Sweden, using the V-PLEX Pro-Inflammatory Panel 1 (human) Kit. Statistically significant differences (p < 0.05) between patient groups and controls were determined using Mann-Whitney U-tests. RESULTS: The CAE patients had significantly higher plasma levels of INF-γ, TNF-α, IL-1β, and IL-8 (p = 0.007, 0.01, 0.001, and 0.002, respectively), and lower levels of IL-2 and IL-4 (p < 0.001 for both) compared to CAD patients and controls. The plasma levels of IL-10, IL-12p, and IL-13 were not different between the three groups. None of these markers could differentiate between patients with pure (n = 6) and mixed with minimal atherosclerosis (n = 10) CAE. CONCLUSIONS: These results indicate an enhanced systemic pro-inflammatory response in CAE. The profile of this response indicates activation of macrophages through a pathway and trigger different from those of atherosclerosis immune inflammatory response. |
| Databáze: | OpenAIRE |
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