Hb S Mobile: A New Genetic Combination
| Autor: | T. D. King, Tsu-Bi Shih, J. Zusman, Richard T. Jones, B. Brimhall, W. B. Smith, Rose G. Schneider |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Genetics Adolescent Hemoglobins Abnormal Hemoglobin Sickle Biochemistry (medical) Clinical Biochemistry Black People Hemoglobin A Hematology Middle Aged Decreased oxygen affinity Biology Blood Protein Electrophoresis medicine.disease Hb SD-Los Angeles Hemoglobinopathy medicine Humans Female Genetics (clinical) Aged |
| Zdroj: | Hemoglobin. 7:521-531 |
| ISSN: | 1532-432X 0363-0269 |
| DOI: | 10.3109/03630268309027933 |
| Popis: | The genetic combination of Hb Mobile (beta 73 Asp replaced by Val) and Hb S (beta 6 Glu replaced by Val) was found in a healthy black man whose hemolysate resembles that of Hb S electrophoretically. His mother and sister have Hb AS; the father and brother have Hb A Mobile. No clinical nor hematologic abnormalities were detected in any member of the family. A slightly decreased oxygen affinity associated with Hb Mobile appears to have no clinical significance. Simple methods of differentiating Hb Mobile S from the electrophoretically similar but clinically severe Hb SD Los Angeles are described. |
| Databáze: | OpenAIRE |
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