Rod-shaped gold nanoparticles exert potent candidacidal activity and decrease the adhesion of fungal cells
| Autor: | Joanna Depciuch, Alexey Maximenko, Robert Bucki, Tomasz Wollny, Jan Kochanowicz, Magdalena Parlinska-Wojtan, Alina Kułakowska, Grzegorz Król, Sylwia Chmielewska, Ewelina Piktel, Piotr Deptuła, Krzysztof Fiedoruk, Łukasz Suprewicz, Mateusz Cieśluk, Bonita Durnaś |
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| Rok vydání: | 2020 |
| Předmět: |
Antifungal Agents
Biomedical Engineering Medicine (miscellaneous) Metal Nanoparticles Bioengineering 02 engineering and technology Microbial Sensitivity Tests Development 03 medical and health sciences Humans General Materials Science 030304 developmental biology chemistry.chemical_classification 0303 health sciences Reactive oxygen species Atomic force microscopy Chemistry Candidacidal activity Fungi Adhesion Drug susceptibility 021001 nanoscience & nanotechnology Colloidal gold Biophysics Gold 0210 nano-technology |
| Zdroj: | Nanomedicine (London, England). 15(28) |
| ISSN: | 1748-6963 |
| Popis: | Aim: To investigate the fungicidal activity of rod-shaped gold nanoparticles (AuR NPs) against Candida strains isolated from hematooncological patients and representative strains of filamentous fungi. Methods: Colony-counting assays, colorimetric and fluorometric methods and atomic force microscopy were employed. Results: AuR NPs were characterized by their potent fungicidal activity against all tested isolates, regardless of the species or drug susceptibility, at concentrations that are nontoxic to the host cells. The membrane-permeabilizing properties of AuR NPs and induction of reactive oxygen species were recognized as crucial for fungicidal activity. Conclusions: The results provide a rationale for the development of nonspherical Au NPs as effective antifungals or drug-delivery carriers to improve therapy for fungal infections. |
| Databáze: | OpenAIRE |
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