Pharmacognostic and acute toxicological evaluation of Scaptotrigona aff. postica propolis extract in pre-clinical assays
| Autor: | Silvana Amado Libério, Flávia R.F. Nascimento, Izabel Cristina Portela Bogéa Serra, Aramys Silva Reis, Eder Magalhães Silva Fialho, Rosane N. M. Guerra, Anne Karine Martins Assunção, Richard Pereira Dutra, Maria Nilce de Sousa Ribeiro, A M C Nogueira, Maria José Abigail Mendes Araújo, Nadia S. Mattar, Adelson S. Lopes |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Low toxicity Traditional medicine Organic Chemistry Alanine Transaminase Plant Science Serum concentration Biology Propolis Bees Alkaline Phosphatase Biochemistry Acute toxicity Analytical Chemistry Enzyme Activation Mice High doses Toxicity Tests Acute Alkaline phosphatase Animals Female Alanine aminotransferase Adverse effect |
| Zdroj: | Natural product research. 25(11) |
| ISSN: | 1478-6427 |
| Popis: | The propolis of Scaptotrigona aff. postica is popularly used in Maranhao State, Brazil, for treating wounds and respiratory illnesses. Nevertheless, little is known about the chemical composition of this propolis and the adverse effects of its use. Hence, this study is a pharmacognostic characterisation of the propolis hydroalcoholic extract (PHE) from S. aff. postica. The methodology consisted of an evaluation of the sensory and chemical parameters. Chemical analysis of PHE indicated high concentrations of phenolic and triterpens substances, and the absence of steroids. Additionally, we evaluated the acute toxicity of propolis using 48 Swiss male and female mice. The animals received single doses of PHE (1000, 2000 or 4000 mg kg⁻¹) orally and were observed for 14 days. After this period, the mice were sacrificed and the blood was used for biochemical and haematological evaluation. PHE did not induce any death, and the acute treatment significantly reduced serum concentrations of alanine aminotransferase and alkaline phosphatase. The resultant data indicate that PHE from S. aff. postica has low toxicity when used orally, even in high doses. |
| Databáze: | OpenAIRE |
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